Astrazeneca-funded Non-clinical Phd Studentship
2 days ago
Project details: Protein expression and purification remain fundamental bottlenecks in biomedical research and drug discovery. Current approaches are time-consuming and often fail to express target proteins at sufficient levels. In this project, you will investigate whether mammalian cell lines can be genetically altered to enhance expression of challenging proteins. Moreover, you will determine whether the success of such alternations depends on protein family and on mRNA characteristics such as codon optimality.
You will construct a panel of engineered cell lines and collect high-throughout measurements of corresponding mRNA and protein levels for several protein targets. Ultimately, you will use these data to develop Matchmaker, a machine learning framework for matching novel protein targets with their optimal expression conditions. Altogether, this project will provide new insights into the mechanisms limiting expression of challenging proteins and how to overcome these barriers.
This position is open to UK citizens or overseas students who meet the UK residency requirements (home fees), or are able to augment the funds to cover the extra costs associated with international student fees through scholarships or funding schemes. Students will not be allowed to supplement fees via self funding.
Funding: This four-year studentship covers University composite fees (at home fees rate), a stipend (£21,500/year) and dedicated consumables and travel budgets.
Deadline: The closing date is 31st October 2025 with interviews held in November.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
**Key information**:
**Department/location**:
Department of Biochemistry
**Salary**:
**Reference**:
PH47279
**Category**:
Studentships
**Date published**:
16 September 2025
**Closing date**:
31 October 2025
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