PK/PD Modeling

1 week ago

London, Greater London, United Kingdom Mercor Full time

This person complements the client's "Translational / Clinical Pharmacology Decision-Maker" team by grounding dose selection and exposure–response analysis in quantitative structure and parameter plausibility.

Who we're looking for

  • Deep hands-on experience in PK, PD, exposure–response modeling, and ideally population PK or QSP.

  • Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces.

  • Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations.

  • Comfortable designing model evaluation rubrics that distinguish between acceptable vs. non-credible outputs.

  • Able to articulate how quantitative checks should complement narrative decision logic.

Nice-to-have:

  • Experience supporting translational or clinical pharmacology leads in dose justification.

  • Familiarity with integrating nonclinical PK/PD data (2-species GLP → human FIH extrapolation).

Experience level

  • ~8–12 years of quantitative pharmacology experience in pharma, CROs, or modeling consultancies.

  • Strong portfolio in population PK/PD, exposure–response, and parameter estimation using NONMEM, Monolix, or equivalent tools.

  • Demonstrated ability to interpret model results for decision-making, not just fit data.

  • Can create fit-for-purpose models and critique model structures or assumptions under uncertainty.

Expectations

  • Design and refine micro-evaluations for PK/PD performance (curve fits, parameter checks, error taxonomies).

  • Encode quantitative sanity checks into model rubrics for automated evaluation.

  • Define failure conditions (e.g., unsafe extrapolation, poor coverage curves, invalid assumptions).

Inputs we give:

  • PK/PD datasets, tox summaries, and performance prompts (e.g., "fit exposure–response curves, interpret safety margins").

  • Example model outputs from automated systems.

Expected outputs:

  • Quantitative Rubrics: clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks.

  • Golden Fit Examples: representative "ideal" PK/PD model outputs and visualizations for calibration.

  • Error Taxonomy: structured list of typical modeling or fitting errors, with root-cause annotations.

  • Meta-Layer Commentary: short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values.

Engagement Model & Compensation

  • Contract / part-time, remote, outcome-based deliverables.

  • PK/PD Module expert: Translational

    1 week ago

    London, Greater London, United Kingdom Mercor Full time

    The client is seeking an external expert who brings a decision-maker's mindset — someone who has personally driven translational pharmacology choices under governance and uncertainty. Who we're looking for Has owned FIH starting dose, SAD/MAD design, and Phase 2 dose selection for multiple assets. Participated in governance or review boards, defending...

  • Pharmacometrician Director H/F

    1 week ago

    London, Greater London, United Kingdom Ipsen Full time $177,000 - $259,600

    Title:Pharmacometrician Director H/FCompany:Ipsen Innovation (SAS)About Ipsen:Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle...

  • Director, Clinical Pharmacology

    1 week ago

    London, Greater London, United Kingdom Recursion Full time

    Your work will change lives. Including your own.The Impact You'll MakeYou will join an innovative and passionate clinical development team dedicated to improving the lives of patients suffering from devastating diseases. You will lead the innovative clinical pharmacology and pharmacometrics strategy and execution for a portfolio of rare disease and oncology...

  • Director, Clinical Pharmacology

    3 hours ago

    London, Greater London, United Kingdom Recursion Full time

    Your work will change lives. Including your own. Please note: Our offices will be closed for our annual winter break from December 22, 2025, to January 2, 2026. Our response to your application will be delayed.  The Impact You'll MakeYou will join an innovative and passionate clinical development team dedicated to improving the lives of patients suffering...

  • Model Developers

    2 days ago

    London, Greater London, United Kingdom Adway Associates Full time

    Moorgate, City of London, EC1The CompanyA specialised risk management and credit modelling consultancy dedicated to helping banks and financial institutions turn regulatory and data challenges into strategic advantages.Founded in 20204 by industry-seasoned professionals with credit risk and banking backgrounds, the company draws on practical, hands-on...

  • Security Modeling Associate

    2 weeks ago

    London, Greater London, United Kingdom BlackRock Full time £80,000 - £120,000 per year

    Locations: London, United KingdomJob descriptionAbout this roleWe are seeking a highly motivated Associate to join the Credit Modeling Team within AFE Single Security. This role is ideal for someone with a strong foundation in quantitative research, econometrics, and a passion for solving complex problems through innovation and collaboration.As part of our...

  • Senior Translational Oncologist

    2 days ago

    London, Greater London, United Kingdom Isomorphic Labs Full time

    Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug...

  • Internal Audit- Model Risk VP

    5 days ago

    London, Greater London, United Kingdom Barclays Full time

    Job DescriptionPurpose of the roleTo support the development of audits aligned to the bank's standards and objectives by working collaboratively with colleagues, providing accurate information and recommendations, and complying with policies and procedures.AccountabilitiesAudit development and delivery support, including financial statements, accounting...

  • Senior Translational Oncologist

    1 day ago

    London, Greater London, United Kingdom Isomorphic Labs Full time

    Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug...

  • Senior Risk Data Scientist

    5 days ago

    London, Greater London, United Kingdom Checkout Full time

    Company DescriptionWe're – you might not know our name, but companies like eBay, ASOS, Klarna, Uber Eats, and Sony do. That moment when you check out online? We make it happen. is where the world checks out. Our global network powers billions of transactions every year, making money move without making a fuss. We spent years perfecting a service most...