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The NIHR Oxford Health Clinical Research Facility (OH CRF) was established in 2011, to support intensive research studies that are not feasible to conduct within the routine clinical care setting primarily in areas of mental health and neurosciences. The OH CRF is funded by the NIHR. The OH CRF is one of 28 facilities across England to benefit from nearly £161 million that has been awarded to expand early phase clinical research delivery in NHS hospitals. OH CRF nurses have opportunities for training with the NIHR, UKCRF network, University of Oxford and many other study specific opportunities.
Nurses may be able to expand their research experience by undertaking research themselves through working with leaders in the field at the University of Oxford Department of Psychiatry and with nurse academics at Oxford Brookes University. Detailed job description and main responsibilities: Clinical Coordinate the care of your own case load of clinical trial patients. Work regularly as a shift coordinator (Nurse in Charge), taking responsibility for the daily coordination of the CRF, providing oversight and guidance to the CRF team and managing any organisational issues that may arise. Work with the CRF Team Lead in the provision of a comprehensive clinical trial service.
Including taking on lead roles and responsibilities within the CRF, to ensure effective and efficient running of the unit. Ensure the safe administration of treatments (IMP) given within the context of a clinical trial, ensuring that treatment is given in accordance with protocol and local policy. This includes the administration of controlled drugs and phase I IMPs. At times, this may include dispensing IMPs.
Undertake clinical assessments for research studies where appropriate, including the completion of mental health assessments, cognitive assessments, standardised interviews and physical health investigations such as side effect scales, ECGs, phlebotomy and vital signs. Develop and maintain clinical skills required to support studies undertaken by the CRF; these include, but are not limited to, nursing support for lumbar puncture procedures, cannulation and IV drug administration. Take an active role in supervision of Student Nurses and Nurse Associate Trainees and Band 5 Nurses. Ensure that trial specific investigations are undertaken as required by the research protocol.
Provide ongoing information, education and support to patients (and their significant others) regarding clinical trials. Maintain accurate documentation of patient/visit events in nursing, medical and trial notes. Review and report adverse events in line with local Trust policies, standard operating procedures, and research specific protocols. Ensure referral to other specialists is made when indicated (e.g.
when tests reveal abnormalities, and specialist opinion needs to be sought) to provide optimal patient care. Act appropriately to record and report serious adverse events, this includes communication with the Principal Investigator and relevant local personnel and regulatory authorities. Provide ongoing follow up care whilst patient is in the clinical trial. Act in a way that always maintains patients and carers dignity.
Act as a primary contact point for the clinical trial participant. Provide regular nursing support to outpatient research clinics running at the Clinical Research Facility currently, a Bipolar Research Clinic and a Treatment Resistant Depression Research Clinic. Clinical support includes physical health assessments such as vital signs, ECGs and phlebotomy. Process biological samples (including centrifuging, pipetting and transporting of samples in accordance with IATA regulations).
Research Assist with the setting up of clinical trials, coordination of trial assessments, identifying pathways for participants and pathways of recruitment in accordance with experience and competency levels. Studies may include large, multi-site clinical trials. Keep the Principal Investigator (PI), CRF manager and the wider study team informed of the progress of clinical trials and of any issues arising. Proactively promote research and the local portfolio of studies widely across the network.
Work according to ICH-GCP and Research Governance standards for all aspects of work practice. Foster links with, e.g., community mental teams, voluntary organisations in order to facilitate recruitment to studies. Identify patients who are eligible to enter clinical trials via discussions with clinicians; and with consent, via electronic records. Contribute to the management of the local portfolio of clinical trials.
Ensure that the clinical trial protocols are adhered to. Facilitate the informed consent process as per legislation and the Mental Capacity Act. Register/randomise patients into trials. Ensure that clinical trial recruitment records are accurately maintained.
Ensure that case report forms are accurately completed, in paper and electronic format. Forward case report data onwards as necessary, adhering to protocol timelines. Supply data as required to internal and external collaborators and management regarding the progress of clinical trials. Contribute to recruitment strategies, identifying any barriers to recruitment to trials and work proactively as part of the study team to maximise recruitment.
Support and assist in the development of action plans as required. For more details, please refer to the attached JD & PS or get in touch with us.
