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Assay Development Scientist

2 weeks ago


Sheffield, Sheffield, United Kingdom Jackson Hogg Full time £60,000 - £90,000 per year

A rapidly growing biotechnology company is seeking an
Assay Development Scientist
to drive the end-to-end development of
single-molecule assay kits
for pharmaceutical research applications. This is a hands-on, cross-functional position bridging product design and manufacturing — ideal for a scientist who combines technical depth with practical experience in developing robust, scalable assay products.

You'll convert product specifications into validated, manufacturable kits optimized for advanced single-molecule detection platforms. The remit spans feasibility assessment, experimental design, optimization, validation, and technology transfer, ensuring each product meets rigorous scientific and operational standards.

Key Responsibilities

  • Translate product specifications into experimental objectives and development plans.
  • Assess assay feasibility, component compatibility, and manufacturability within single-molecule workflows.
  • Develop and optimize fluorescence-based assays (e.g. smFRET, FCS, FCCS).
  • Design and execute analytical validation studies for sensitivity, precision, and reproducibility.
  • Define and implement quality control criteria and documentation for manufacturing transfer.
  • Collaborate closely with Manufacturing, Quality, and Product Management to ensure seamless scale-up.
  • Provide technical data and support for pharmaceutical customer applications.

Essential Skills and Experience

  • PhD (or equivalent industry experience) in Biophysics, Biochemistry, Chemistry, or a related discipline.
  • Proven track record in assay development, optimization, and validation for industrial or pharmaceutical use.
  • Experience translating research assays into reproducible kit formats.
  • Strong experimental design and quantitative analytical skills.
  • Excellent documentation and communication abilities.
  • Proven success managing cross-functional development projects.

Preferred

  • Hands-on experience with single-molecule fluorescence techniques (smFRET, FCS, FCCS).
  • Expertise in biochemical assay development for proteins, nucleic acids, or complex molecular systems.
  • Familiarity with pharmaceutical assay development, kinetics, or screening.
  • Exposure to design-for-manufacture, GLP, or ISO 13485-aligned frameworks.

The Offer

  • Competitive salary
  • Share options
  • 4% employer pension contribution
  • 26 days annual leave
  • On-site, collaborative R&D environment
  • Opportunity to shape a new generation of high-performance molecular assays for the pharmaceutical industry