Senior LCMS Scientist

4 days ago

Southampton, Southampton, United Kingdom Cranleigh STEM, Sustainability & SHEQ Recruitment Full time

Senior Scientist – Subject Matter Expert (SME) in Mass Spectrometry

Up to £45,000 + Benefits

Full-time, On-site – Southampton

We're partnering with an innovative scientific organisation to find an experienced
Senior Scientist
with deep expertise in
Mass Spectrometry
to join a high-performing team based in Southampton. This role offers the chance to lead analytical strategies, contribute to cutting-edge projects, and support the development of high-quality modified nucleic acid in a fast-paced, collaborative environment.

About the Role

As the subject matter expert in mass spectrometry, you'll play a central role in driving analytical method development, ensuring high standards in nucleic acid production, and mentoring junior team members. This is a hands-on role in a modern laboratory, where scientific excellence and operational efficiency go hand-in-hand.

Key Responsibilities

  • Lead and manage analytical workflows using LC-MS, UPLC-MS, HPLC, PAGE, and flash chromatography
  • Act as the go-to expert for mass spectrometry, including troubleshooting and continuous improvement
  • Collaborate with cross-functional teams to support small molecule preparation and oligonucleotide synthesis
  • Maintain, calibrate, and optimise analytical instrumentation in line with internal and ISO quality standards
  • Support and mentor Associate Scientists and Lab Technicians, providing technical guidance and training
  • Ensure high levels of documentation accuracy and data integrity
  • Uphold Health, Safety and Environmental (HSE) standards and promote a safety-first culture
  • Manage the inventory of analytical reagents and consumables
  • Stay informed on emerging techniques in nucleic acid chemistry and analytical science

About You

We're looking for a driven and detail-focused scientist who thrives in a collaborative lab environment and is passionate about pushing the boundaries of analytical science.

You'll ideally have:

  • PhD in Chemistry, Analytical Chemistry, or a closely related field
  • Significant hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Waters Connect experience highly desirable)
  • Proven track record in high-throughput chemistry or oligonucleotide production environments
  • Strong grounding in nucleic acid chemistry and experience with purification techniques
  • Experience working in ISO or GMP-regulated environments
  • Ability to lead projects and mentor junior staff
  • Excellent communication, problem-solving and organisational skills
  • A proactive mindset, able to adapt and perform under pressure

Salary & Benefits

  • Salary:
    Up to £45,000 depending on experience
  • Location:
    On-site in Southampton
  • Holidays:
    25 days annual leave + 8 bank holidays
  • Pension:
    6% employer contribution
  • Work-Life Balance:
    Flexible working hours
  • Life Assurance:
    4x salary
  • Other Benefits:
  • Long service awards
  • Reward and recognition scheme
  • Employee Assistance Programme with 24/7 remote GP access
  • Annual flu vaccinations
  • Cycle to work scheme
  • Gym discounts
  • Discount and savings platform
  • Professional membership reimbursement
  • Referral incentives
  • Social events and volunteering days

Want to lead innovation in mass spectrometry and oligonucleotide production?

If you're ready to make an impact in a dynamic and supportive environment, we'd love to hear from you. Apply today or get in touch to learn more.

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