Postdoctoral Research Scientist in Cardiovascular 3D in vitro Systems
2 weeks ago
ResponsibilitiesBefore applying for this role, please read the following information about this opportunity found below.Engineer and validate human pluripotent stem cell (hPSC)-derived 3D cardiac platforms, including multicellular organoids and high-throughput cardiomyocyte spheroids.Develop and apply live-cell reporter systems for quantifying proliferation and regeneration.Benchmark and optimise AAV and RNA-based vector delivery across cardiac tissue platforms.Implement quantitative functional assays (e.g. calcium imaging, electrophysiology, contractility, ECM analysis).Collaborate with REACT partners to integrate validated assays into the cross‑institutional screening pipeline and test nominated regenerative candidates.Manage day‑to‑day project planning, data analysis and reporting to leadership.Prepare manuscripts, present results at internal and external meetings and contribute to the Oxford Organoid Hub training and outreach.QualificationsHold, or be close to completion of, a PhD/DPhil in developmental or stem cell biology, molecular genetics, cardiovascular sciences, or a related discipline.Strong experience in mammalian cell culture, ideally hPSC differentiation and/or 3D tissue models.Proven track record in molecular biology and/or live-cell imaging.Ability to work independently and collaboratively in an interdisciplinary environment.Excellent communication, organisational and analytical skills.Commitment to scientific integrity, equality, diversity and inclusion in the workplace.About the DepartmentAt the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.About the Oxford Organoid HubThe Oxford Organoid Hub is a cross‑departmental centre of excellence driving innovation in human model systems for discovery and therapeutic testing. The Hub provides access to scalable, engineered organoid and microtissue systems that model cardiac physiology, disease and regeneration. It brings together expertise in stem cell and developmental biology, tissue engineering, imaging and computational analysis to accelerate translation of human‑relevant models.Overview of the RoleThe post‑holder will join the MRC‑BHF REACT‑funded project "Engineering Human 3D Cardiac Platforms for Regenerative Therapy Screening", led by Dr Filipa Simões and Dr Chris Toepfer. The project aims to deliver scalable, human‑specific cardiac assay systems and reporter tools for the discovery of RNA and gene therapies targeting regeneration, angiogenesis and fibrosis. xpwpeyx Working at the interface of cardiac organoid biology and therapeutic screening, the post‑holder will play a central role in developing and validating next‑generation cardiac assay platforms integrated into REACT's cross‑institutional screening pipeline.BenefitsHybrid workingAn excellent contributory pension scheme38 days annual leaveA comprehensive range of childcare servicesFamily leave schemesCycle and electric car loan schemesEmployee Assistance ProgrammeMembership to a variety of social and sports clubsDiscounted bus travel and Season Ticket travel loans#J-18808-Ljbffr
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Oxford, United Kingdom University of Oxford Full timeResponsibilities Engineer and validate human pluripotent stem cell (hPSC)-derived 3D cardiac platforms, including multicellular organoids and high-throughput cardiomyocyte spheroids. Develop and apply live-cell reporter systems for quantifying proliferation and regeneration. Benchmark and optimise AAV and RNA-based vector delivery across cardiac tissue...
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Oxford, United Kingdom Professor Doctor Obi Full timeAbout the Oxford Organoid Hub The Oxford Organoid Hub is a cross‑departmental centre of excellence driving innovation in human model systems for discovery and therapeutic testing. The Hub provides access to scalable, engineered organoid and microtissue systems that model cardiac physiology, disease and regeneration. It brings together expertise in stem...
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Oxford, United Kingdom Professor Doctor Obi Full timeAbout the Oxford Organoid HubIf you are considering sending an application, make sure to hit the apply button below after reading through the entire description.The Oxford Organoid Hub is a cross‑departmental centre of excellence driving innovation in human model systems for discovery and therapeutic testing. The Hub provides access to scalable, engineered...
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