Scientist – Translational Medicine

7 days ago

Oxford, United Kingdom Immunocore Full time

Location UK – Oxford Department Translational Medicine Key Responsibilities The Translational Medicine Lab plays a pivotal role at Immunocore, generating biological data from both clinical trial and pre‑clinical experimental samples to advance understanding of our platform and ultimately improve patients’ health. We are now looking for an enthusiastic Scientist to join our team. The successful candidate will design and conduct experiments to investigate the mechanism of action of our ImmTAX therapies, test predictive hypotheses using pre‑clinical models and patient‑derived samples, and contribute to the advancement of our therapeutic pipeline. Design, conduct, and analyse experiments and record data in a timely manner following Company procedures. Keep abreast of technical advances in relevant fields through self‑study and attending training sessions and conferences. Communicate results internally in lab meetings and seminars and externally at relevant conferences. Operate in accordance with the Company’s health and safety policies. Mentor other scientists by providing scientific advice and technical support. Education, Experience and Knowledge Essential Qualifications Knowledge of cancer biology, T‐cell biology and immunotherapies. In depth experience in a range of cellular techniques and immunoassays: Molecular biology techniques, including generation and validation of stable overexpression (Lentiviral transduction) and CRISPR KO in cancer and/or T cells. Experience with 3D (spheroid and organoid) culture models. PBMC isolation and cell subset purifications. T‑cell functional assays including cytokine release assays and killing assays. Excellent oral and written communication skills. Demonstrated ability to plan and work to agreed deadlines. The ability to work both independently and as part of a team. Demonstrated record of scientific accomplishments, including publications and presentations at conferences. Desirable Expertise in imaging by confocal microscopy and high‑throughput imaging systems. Ex vivo analysis of tumour biopsies and tumour infiltrating lymphocytes. Research experience with both solid and liquid tumour models. Broad understanding of immunology spanning cancer immunotherapy, infectious diseases, and autoimmunity. Experience in application of GCP principles to the analysis of clinical trial samples. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial‑stage T cell receptor biotechnology company whose purpose is to develop and commercialise a new generation of transformative medicines that address unmet patient needs in oncology, infectious diseases and autoimmune disease. The company’s leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. Immunocore’s ImmTAX molecules underpin a new generation of precision‑engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. Immunocore is proud to be an equal‑opportunity employer. We are committed to fostering an inclusive workplace where everyone feels valued, respected and empowered, and encourage applications from individuals of all backgrounds, regardless of race, colour, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status or any other characteristic protected by law. Seniority level Entry level Employment type Full‑time Job function Research, Science and Engineering #J-18808-Ljbffr

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