Associate Principal Scientist, Protein Scientist
3 days ago
Company Description
Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines. Our pipeline includes Bicycle Toxin Conjugates® as well as fully synthetic Bicycle® systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need. Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.
**Culture** is key and all Bicycle employees actively embrace and role model our company values:
- We are **Adventurous**. We believe it’s the way to deliver extraordinary results for our patients.
- We are **Dedicated to our Mission**. You can’t change the world if you don’t have determination.
- We are **One Team**. We only succeed when we work together.
**Job Description**:
We have an exciting opportunity for a highly skilled Associate Principal Scientist to join our Protein & Cellular Sciences Team: You will join a small team dedicated to acquisition and production of high-quality recombinant protein material to facilitate the Bicycle discovery platform.
**Key responsibilities**
- Support multiple Discovery campaigns by acting as key point of contact for stakeholders, understand project requirements, provide scientific guidance on protein-related matters
- Research target biology and identify necessary reagents to progress programs
- Design, express, and purify recombinant proteins using eukaryotic & prokaryotic systems
- Organise and direct work with CROs as appropriate to diversify/increase throughput
- Drive scientific excellence in the team by championing process improvements, help the team imbed best practice, review data generated by the team and develop SOPs as needed
- Management of our protein quality control process including summarising your own and other peoples BLI, mass spectrometry, SDS-PAGE & SEC-MALS data.
- Collaborate with our informatics team to further integration of protein quality control data into electronic lab notebooks and relevant reporting systems, working with the database manager to add or improve functionality where necessary, automate processes where possible and facilitate data sharing across functions
- Independently problem-solve, troubleshoot, and identify next steps and solutions
- Present interpreted data and conclusions of independently conducted research effectively in oral or written form to internal team and external partners, including possible next steps to drive projects forward
- Interact and communicate efficiently in a collaborative environment involving cross-functional teams of biologists and chemists
- Organise, plan and coordinate work with broader protein sciences team
Qualifications*
Essential:*
- Relevant academic or industry experience with a focus on protein science
- Extensive experience in a biotech or industrial environment
- Comprehensive understanding of molecular biology and protein production from eukaryotic and prokaryotic systems including antibody production
- Extensive practical experience in protein purification with AKTA systems including affinity chromatography, HIC, IEX, and SEC
- Hands-on experience of a range of biophysical and/or biochemical assay techniques to characterise protein function, including BLI, SPR and SEC-MALS
- Experience managing projects or processes
- Ability to prioritise and adapt work to facilitate delivery to timelines
- Strong interpersonal skills along with data presenting & reporting
- Diligent in documenting work and adherent to data integrity requirements
**Desirable**:
- A PhD in Biochemistry with a focus on protein science
- Experience in DNA assembly methods
- An understanding of structural biology
- Ability to interpret mass spectrometry data
- An understanding of phage display or other display technologies
- Prior experience of line management (if line management is desired)
Additional Information
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover
- Enhanced parental leave policies
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
- Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not dis
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