MRC Postdoctoral Research Scientist LMS 2733

View Vacancy -- MRC Postdoctoral Research Scientist LMS 2733 Open Date 18/11/2025, 09:55 Close Date 31/12/2025, 23:55 Research Institute MRC Laboratory of Medical Sciences Research Institute / Unit Information The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. We are proud to launch our new Team Science initiative, marking a bold step toward a more collaborative, challenge-driven model of research. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org Band MRC - 4 Location London Salary £42,694 per annum plus London allowance £5,560 per annum Allowances Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two and £1,800 in year three. Contract Type Fixed Term Job Type Science Full Time / Part Time Full Time Contract Length 3 years Job Description Team Science:The MRC Laboratory of Medical Sciences (LMS) is proud to launch its new Team Science initiative, marking a bold step toward a more collaborative, challenge-driven model of research. Scientific breakthroughs are often portrayed as the work of lone geniuses, but in reality, they are usually the result of collective effort. A Team Science project is not just bigger or multi-part, it's fundamentally different in its ethos and operational model. It's designed to foster true collaboration across disciplines, academic institutions, industry and the public, creating something that could not be achieved alone. It's about collective ambition, shared infrastructure and interdisciplinary innovation. This new approach places collaboration and real-world impact at its core, integrating insights from across the LMS' existing expertise and diverse perspectives. Overall purpose: A new exciting opportunity has arisen for a 3 Year Postdoctoral Research Scientist to join the Reproductive Health and Fertility: Ageing, Sex and the Environment Team science project led by J Vaquerizas, E Martinez-Perez, and P Hajkova. Reproductive health is an important aspect of human wellbeing, yet infertility affects approximately one in six people globally. Despite its prevalence and significant emotional, societal and economic impact, the biological mechanisms underlying infertility and reproductive ageing remain poorly understood. We have put together a team of internationally-leading experts in germline biology and genome function that will use transdisciplinary experimental approaches to understand how intrinsic and extrinsic factors influence female and male fertility and reproductive ageing. We are looking for a talented and self-motivated computational biologist with an interest in reproductive biology and genome function to join the Reproductive Health and Fertility: Ageing, Sex and the Environment Team science initiative as a postdoctoral researcher . The main goal of the project will be to analyse and integrate multimodal genome-wide datasets to build predictive models of healthy reproductive processes and investigate how these are perturbed in infertility and ageing. The candidate will work closely with other postdocs and students in the Team who will use omics and imaging approaches to elucidate the genetic and molecular causes of infertility, the impact of aging in male and female fertility, and the effect of metabolism and germline-soma crosstalk on fertility. Main duties / key responsibilities: Design, plan, and conduct high-quality, independent research aligned with the project aimsCritically analyse, interpret, and present experimental data with scientific rigor and reproducibilityStay current with relevant scientific literature and integrate new findings and methodologies into ongoing researchCollaborate effectively with internal lab and Team members and external partners, including participation in interdisciplinary projectsProvide training and advice for other group members including PhD studentsWrite-up and publish results in high-quality, peer-reviewed scientific journalsTake an active part in the academic activities of the LMSAttend and contribute to lab meetings, journal clubs and seminar presentationsPresent data at national and international meetings (where and when appropriate)Form good working relationships with other members of the group as well as internal and external collaborators Person Specification Education / Qualifications / Training required (will be assessed from the application): Essential: PhD (or equivalent experience) in computational biology or in a relevant field (e.g., bioinformatics, molecular biology, cell biology, biochemistry, developmental biology, genetics)A first-author manuscript published or submitted from PhD workPrevious work experience required (will be assessed from the application and at the interview): Essential: Proven experience in single-cell omics data analysis and visualisationProficiency in Python and/or RExperience with statistical analysis, machine learning methods, and high-performance computing Desirable: Experience with spatial transcriptomics, 3D genome analysis, or epitranscriptomicsExperience with multiomic data integration techniquesIntegration of transcriptomic, epigenomic, and/or proteomic dataNetwork analysis and trajectory modellingAI-assisted mutation prioritisationKnowledge and experience (will be assessed from the application and at the interview): Essential: Strong conceptual understanding of genomics, gene regulation, developmental biology, computational biology approachesExperience in generating high-quality figures for publicationExcellent written communication skills in EnglishEvidence that the candidate can plan and carry on a research project Desirable: Strong publication record and exposure to scientific meetingsExperience with GWAS and regulatory variant interpretationStrong programming and statistical modelling skillsExperience in assembling manuscripts for publicationExperience presenting scientific data at national or international conferencesPersonal skills/behaviours/qualities (will be assessed at the interview): Essential: Enthusiastic and motivated, with a genuine interest in scientific discovery and learningIndependent research capability, including the ability to manage and drive projects autonomouslyCollaborative mindset, with the ability to work effectively in a team-oriented research environmentEagerness to learn, particularly in computational and analytical approachesCreativity and problem-solving skills, especially when troubleshooting complex challengesExcellent verbal communication skills in English, with the ability to present ideas clearly and confidentlyGood interpersonal skills, including the willingness to give and receive help and feedbackCommitment to knowledge sharing and mentoring within the groupHighly organised and diligent, with strong attention to detailAdaptability and openness to integrating new techniques and collaborating across disciplinesExcellent laboratory skillsExcellent organisational skillsExcellent attention to detailsExcellent creativityHigh-Motivation and perseveranceAbility and willingness to adapt to changing timetables or work patterns as dictated by changing circumstancesAbility to work under pressure while maintaining a high degree of accuracyProven ability to prioritise, plan ahead and manage a high volume of work to meet deadlines, both prescribed and self-imposedAbility to use own initiative and work independently and as part of a team, as requiredProblem solving abilitiesProven multitasking abilitiesAbility to work in a collaborative research environmentWillingness to give and receive help with challenging problemsGood verbal communication skills in EnglishAbility to communicate its science in a clear wayGood interpersonal skillsWillingness to share knowledge and transfer skills to other members of the group on a daily basis Further Information Please upload your CV, names and contacts of two scientific references, along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Please quote reference number LMS 2733. Please note that applications may be reviewed by both LMS and Imperial staff The MRC is a unique working environment where scientific researchers and professional support staff can actively partake in world class innovation and collaboration opportunities and their skills and knowledge through accessing a wide catalogue of training & development, including professional registration with the Science Council. In addition, MRC (part of UKRI) provides its community of employees access to a whole host of useful benefits, including a defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We warmly invite people from diverse backgrounds and heritage, including people who identify as having a disability, to apply for a role that excites them. As "Disability Confident" employers, we guarantee to interview all applicants who have disclosed they have a disability and who meet the minimum criteria for the vacancy. UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs. We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.