QC Technologist
2 weeks ago
Job Title: QC Technologist - Global Biopharmaceutical
Contract: 12 months
Location: Cambridge
Salary: £15.80
Hours: 37.5 hours per week
This is a great opportunity for a graduate in a biochemistry related degree looking for their first role in the industry. 0-2 years industry experience is required for this role.
This role is for The Cell Engineering group, based in Cambridge UK, it is a pivotal member of Mammalian Expression System Centre, focused on improving host cell line functionality through cutting edge science and technology innovations. As a Technologist - Cell Engineering you will support the delivery of R&D projects.
Key Responsibilities will include:
Contribute to the delivery of new mammalian expression hosts and vector systems for the expression of complex therapeutic proteins.
Engineer mammalian cell lines (e.g. random integration, targeted integration and gene editing - e.g. CRISPR-based systems).
Generate mammalian expression vectors using state of the art assembly techniques.
Phenotypic characterisation of edited cell lines with relevant assays (e.g. NGS, ddPCR, qPCR and flow cytometry) and cell culture techniques (e.g., shake flask/ bioreactor).
Collate, analyse, evaluate and sign-off data to produce good quality information and traceable records under the direction of the project lead.
Presentation of results in written and oral reports.
Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein expression (in particular with R&D Process Development, Microbial Expression & Protein Analytics)
Actively keep abreast of relevant academic literature (e.g., in the field of cell engineering and expression technologies).Candidate Requirements:
BSc/MSc Degree in Life Sciences / Science/ Molecular Biology
Practical experience within in an industrial/academic setting is desirable.
Good technical background in molecular biology (electrophoresis, PCR, vector construction) and cell culture (preferably mammalian cells) with the aim of developing or manipulating mammalian expression systems.
Clear demonstration of strong technical skills, scientific execution and data analysis.
A proactive attitude to working and solving challenging problems.
Good working knowledge of statistics and expertise in design of
Experience of cell line engineering, ideally with CRISPR-based systems would be an advantage and highly desirable.
Good understanding of synthetic biology technologies would be desirable.Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy
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