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Sample Technologies Manager

2 months ago


Oxford, Oxfordshire, United Kingdom Oxford Nanopore Technologies Full time
About the Role

Oxford Nanopore Technologies is seeking a highly skilled Sample Technologies Manager to join our RNA/cDNA Sample Technologies team. This is a full-time, lab-based position that involves the research and development of our sequencing kits to enhance the performance of our RNA/cDNA sequencing platforms and end-to-end workflows for biopharma-related applications.

Key Responsibilities
  • Design and implement experiments to improve RNA/cDNA sequencing protocols and kits, including techniques for direct RNA and cDNA sequencing methodologies.
  • Extract and prepare nucleic acid for RNA and/or DNA sequencing.
  • Develop and maintain specific assays and protocols, including RNA/cDNA sequencing sample prep, transcriptome sequencing, barcoding, sequence capture/enrichment, and modified base detection.
  • Generate sequencing data for downstream bioinformatic analysis.
  • Liaise with bioinformatics/software development teams to provide required sequencing data to a defined experimental design.
  • Communicate experimental findings with key stakeholders, including writing protocols for publication.
  • Generate and curate QC data and sequencing data to support sample prep methodologies as they are developed and investigated.
  • Work with relevant stakeholders to deliver methodologies congruent with Q-line and regulatory GMP practices.
  • Work on own projects as well as assist new team members with lab work and basic bioinformatics tasks.
Requirements
  • Postgraduate Ph.D. degree and postdoctoral experience in a molecular biology/biotechnology-based field, or several years of related industry experience, preferably in an RNA-related discipline.
  • Background with a successful lab-based academic research project or relevant lab-based work experience, and an understanding of next-generation sequencing.
  • Leadership experience of laboratory-based research projects and/or teams is desired.
  • Knowledge, skills, and abilities in the following areas: basic understanding of nucleic acid structure and function, experience working with RNA, some data analysis/stats skills, familiarity with basic molecular biology lab procedures, ability to perform basic lab calculations, organisational, interpersonal, and communication skills, and previous managerial experience is highly desirable.
What We Offer

Oxford Nanopore Technologies offers an attractive bonus, generous pension contributions, private healthcare, and an excellent starting salary. The company is based within beautiful, landscaped surroundings with tree-lined walks, water features, and a lake, making for a wonderful working environment.