Senior Vascular Biology Researcher

5 days ago


London, Greater London, United Kingdom UCL Eastman Dental Institute Full time

About the Role

The Brain Vasculature and Perivascular Niche Group focuses on vascular growth and the development of blood vessels in the brain, including endothelial cells and perivascular cells of the neurovascular unit/perivascular niche. The main aims are:

  1. to understand the cellular and molecular underpinnings that govern the growth of the developing, adult, and diseased human brain vasculature at single-cell resolution
  2. to uncover the single-cell transcriptomic, genomic and epigenomic landscapes and spatial biology of the developing, adult and diseased human brain vasculature
  3. to elucidate how developmental programs regulate vascular growth/angiogenesis in the human brain tumour vasculature (patho-fetal axis/onco-fetal axis)
  4. to unravel the onco-fetal programs of vascular growth/angiogenesis and immunosuppression/immunomodulation
  5. to translate these fundamental insights about the onco-fetal axis in the human brain (tumour) vasculature into clinical settings with the ultimate goal to identify novel therapeutic strategies for human brain tumours (and for other vascular-dependent diseases such as human brain vascular malformations)


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