Cell and Gene Therapy Method Developer

22 hours ago


London, Greater London, United Kingdom Orchard Therapeutics Full time
About the Role

This 15-month fixed-term contract offers an exciting opportunity to join Orchard Therapeutics' Global Analytical Development Team as a Scientist. You will contribute to the development and qualification of analytical methods for cell and gene therapy programs.


Key Responsibilities

Your key responsibilities will include:

  • Designing and executing experiments to develop and qualify analytical methods.
  • Maintaining accurate records and final reports to support internal analytical assay development activities.
  • Developing and performing analytical methods, including protein and cell-based tools, immunoassays, and ddPCR.
  • Evaluating novel equipment and methodologies.
  • Tissue culture of primary cells, cell lines, and cell bank generation.
  • Writing SOPs to support activities, including tech transfer to internal departments or external partners.
  • Presenting method development plans and results to the wider department and functional teams.
  • Supporting development and qualification of analytical methods at CMOs and CTOs.

Requirements

To be successful in this role, you will require:

  • A PhD with >1 year post-doc experience or equivalent level of experience in industry following BSc/MSc in biotech-related discipline.
  • Experience in executing flow cytometry experiments and/or single cell-based assays.
  • Assay development experience with excellent problem-solving and troubleshooting abilities.
  • A proven understanding of analytical techniques, including flow cytometry, enzymatic activity assessment, immunoassays, and protein detection.


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