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Senior Oligonucleotide Synthesis Specialist

1 month ago

Didcot, Oxfordshire, United Kingdom Oxford Nanopore Technologies Full time

Job Summary

Oxford Nanopore Technologies is a leading company in the field of sequencing technologies. We are seeking a highly skilled Senior Oligonucleotide Synthesis Specialist to join our team in expanding the nucleotide and oligonucleotide synthesis capabilities aimed at research and development within a newly established oligonucleotide facility.

Key Responsibilities

  • Developing an oligonucleotide synthesis pipeline to serve critical R&D projects.
  • Developing synthesis methodologies for complex, modified and long DNA/RNA oligonucleotides.
  • Improving purification and analytical workflows for synthesised oligonucleotides, introducing automation where possible.
  • Analysing oligonucleotides by high-resolution CE, LC-MS and HPLC.
  • Onboarding new technology and methods to improve operational effectiveness.
  • Contributing to the scientific and technical training of the team.
  • Promoting a safe working environment for all team members and a culture of continuous improvement for health & safety.
  • Preparing clearly articulated progress reports and keeping well-organised experimental records.

Requirements

  • BSc, MSc or PhD degree in chemistry with industrial or equivalent experience.
  • Strong experience in oligonucleotide synthesis.
  • Nucleosides, phosphoramidites and triphosphates synthesis experience would be a plus.
  • Practical knowledge of small molecules and oligonucleotide analysis and purification.
  • Strong problem solving and analytical skills.
  • Strong attention to detail and a high level of organisation.

What We Offer

We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment.