Cryo-EM Facilities Manager

1 month ago


Stevenage, Hertfordshire, United Kingdom GSK Full time
Cryo-EM Facilities Manager

The UK Structural & Biophysical Sciences group at GSK is a global multi-disciplinary department that provides molecular insights into drug discovery for various programs.

This role is an excellent opportunity for a team-oriented individual who is keen to apply their skills in managing a highly productive cryo-EM facility. Your role will encompass troubleshooting, calibration, and regular upkeep to ensure optimal performance.

In this pivotal role in drug discovery, you will collaborate with researchers both within and outside the department, leveraging cryo-EM to directly impact the advancement of medicines. Staying abreast of the latest developments in cryo-EM technology is vital, ensuring that our team and facility remain at the forefront of the field.

Key Responsibilities
  • Oversee and operate three state-of-the-art cryo-EM microscopes, ensuring their optimal performance.
  • Help design future cryo-EM infrastructure strategy and evolve efficient ways of working.
  • Establish strong and productive relationships with manufacturers to ensure the best support and updates for the equipment.
  • Ensure awareness of developments in cryo-EM to maintain the department at the forefront of the field.
  • Adhere to the highest standards of quality and safety.
Requirements
  • A background in a biological, biochemical or physical sciences discipline, with at least PhD level or equivalent experience.
  • Extensive experience with operation of screening and high-resolution data-collection microscopes.
  • Knowledge of all stages of the single particle cryo-EM process from protein purification to grid optimisation, data-processing, 3-D reconstruction and structure interpretation.
  • Postdoctoral/industrial experience in structural biology.
  • Examples of training scientists in one or more areas of the cryo-EM process.
  • Experience of integration of microscope data into HPC ecosystems.
  • Experience of maintaining microscopes and interacting with external support/ engineers.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive.



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