Research Scientist
4 weeks ago
**Opportunity for a 4-Year PhD Studentship**
We are seeking an exceptional candidate to join our research team in the Department of Medicine and the AstraZeneca Discovery Centre at Cambridge. The successful applicant will have the unique opportunity to work on a collaborative project jointly supervised by Prof Ravi Gupta and Dr. Daniele Corridoni at AstraZeneca, aiming to train independent, innovative scientists capable of pursuing translational research.
Project Overview
The project, entitled Macrophage-induced cytokines and cell cycle state in cancer and inflammatory diseases, is a cutting-edge research area that has generated much excitement in both academia and industry. Macrophages have diverse phenotypes and functions depending partly on the microenvironment they reside in and play important roles in a range of conditions such as inflammatory arthritis, wound healing, cancer and infectious diseases.
We have built a body of work on the impact of cell cycle transitions on macrophage biology and identified that low oxygen conditions drive macrophages from G0 to G1 via a HIF2 directed transcriptional program with activation of the MEK/ERK proliferation pathway. We find secretion of IL1b, a pro-metastasis and pro-tumour molecule, is upregulated. This is pertinent given tumour associated macrophages are in a hypoxic environment. These observations are consistent with our data showing 'quiescent' G0 macrophages residing are highly sensitive to TLR4 activation compared to those in G1.
We will deploy a range of techniques to address the link between cell cycle regulation, tumourigenesis and inflammation. Our data could potentially be leveraged to modulate innate immune responses in diseases through drugs that modulate the cell cycle.
What We Offer
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. Full details of the University's entrance requirements and scholarships are specified on the following link.
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