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Structural Biologist
4 weeks ago
Job Title: Research Associate
Job Summary:
We are seeking a highly motivated Research Associate to join our team at the University of Bristol. The successful candidate will be responsible for investigating the free fatty acid-binding pocket in the SARS-CoV-2 Spike protein.
Key Responsibilities:
- Produce SARS-CoV-2 spike mutants using MultiBac insect cell expression
- Confirm that LA binding is abrogated
- Characterise ACE2 receptor binding and stability of the spike mutant using biophysics
- Solve the structure of the best SARS-CoV-2 spike mutant protein by single particle cryo-EM and in situ in the context of mutant SARS-CoV-2 using cryo-tomography
Requirements:
- PhD in Structural Biology, Biochemistry, Biophysics or related
- Published experience in protein expression and purification, biophysical characterization, Cryo-EM and image processing
Working with Us:
As a Research Associate at the University of Bristol, you will have the opportunity to work with a talented team of researchers and contribute to cutting-edge research in the field of SARS-CoV-2 Spike protein investigation.
About Us:
The University of Bristol is a world-renowned institution with a strong reputation for research excellence. Our team is dedicated to advancing our understanding of the SARS-CoV-2 Spike protein and its role in viral infection and replication.
