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Research Scientist, In Vivo Pharmacology Expert
2 months ago
Bicycle Therapeutics is seeking a highly skilled Research Scientist to support the preclinical research and discovery efforts for our expanding portfolio of Bicycle-based therapeutics.
This individual will have a passion for developing innovative treatment paradigms for cancer patients and will enjoy working collaboratively across programs.
The successful candidate will report to the Associate Director of In Vivo Pharmacology.
Key Responsibilities- Design and Interpret In Vivo Pharmacology Studies: Develop and execute in vivo pharmacology studies to evaluate the activities of Bicycle Toxin Conjugates (BTC), Bicycle Radio Conjugates (BRCTM), and other compounds in our pipeline, including their mechanism of action and PK/PD/efficacy relationships.
- Manage In Vivo Pharmacology Research: Oversee in vivo pharmacology research through a network of Contract Research Organizations (CROs) and academic collaborations.
- Collaborate with Cross-Functional Disciplines: Effectively collaborate with cross-functional disciplines, including biology, DMPK, translational sciences, and toxicology, to drive decisions and advance our pipeline.
- Document and Communicate Results: Effectively document and communicate results company-wide in diverse settings, ranging from project team meetings to internal scientific forums.
- Identify and Validate Pharmacodynamic Biomarkers: Identify and validate pharmacodynamic biomarkers to support preclinical and clinical development.
- Lead In Vivo Pharmacology Sample Management: Oversee in vivo pharmacology sample management.
- Author Publications and Presentations: Author publications in peer-reviewed journals and represent Bicycle at conferences with scientific presentations in poster or oral formats.
- Educational Background: Educated in a biological sciences field with extensive industrial experience.
- Hands-on Experience: Hands-on experience using multiple types of in vivo oncology models is required.
- Experience with Toxin- or Radionuclide-Conjugates: Experience in working with toxin- or radionuclide-conjugates (e.g., ADCs, radiopharmaceuticals) is preferred.
- Experience in In Vivo Model Development and Validation: Experience in in vivo model development and validation is preferred.
- Knowledge and Experience in Pre-clinical In Vivo SPECT or PET Nuclear Medicine Imaging Techniques: Knowledge and experience in pre-clinical in vivo SPECT or PET nuclear medicine imaging techniques, including understanding of theory, familiarity with data acquisition and analysis techniques, and experience in quality control and presentation of such data, is desired.
- Experience in Managing External Work/Collaborations: Some experience in managing external work/collaborations is preferred.
- Strong Background in Cancer Biology: A strong background in cancer biology is preferred.
- Collaborative and Multidisciplinary Teamwork: Capability of working both independently and as part of multiple collaborative and multidisciplinary teams.
- Attention to Detail and Strong Interpersonal Skills: Attention to detail and strong interpersonal, organizational, and communication skills.
- Innovative and Entrepreneurial Mindset: Innovative, entrepreneurial, and enjoys working in a fast-paced, small-company environment.
- State-of-the-art Campus Environment: State-of-the-art campus environment with on-campus restaurant and Montessori nursery.
- Flexible Working Environment: Flexible working environment.
- Competitive Rewards: Competitive rewards, including annual company bonus.
- Employee Recognition Schemes: Employee recognition schemes.
- Generous Leave Policy: 28 days annual leave in addition to bank holidays, plus option to buy up to 5 additional days annually.
- Pension and Life Assurance: Employer contribution to pension and life assurance cover 4x basic salary.
- Private Medical Insurance: Private medical insurance, including optical and dental cover.
- Group Income Protection: Group income protection.
- Employee Assistance Program: Employee assistance program.
- Health Cash Plan: Health cash plan.
- Access to Subsidized Gym Membership: Access to company-subsidized gym membership.
- Option Grant: Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to Work Scheme: Cycle to work scheme.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.
