Research Scientist
14 hours ago
Job Description
We are seeking a highly skilled Research Scientist to join our dynamic research team at Newcastle University. The successful candidate will be responsible for performing large-scale genetic analyses on patient cohort data to define nuclear determinants of mitochondrial DNA disease phenotypes.
The ideal candidate will have knowledge and experience of applying statistical genetic techniques such as GWAS, LMM etc. They will also have experience of working within a Unix/Linux HPC or cloud computing environment and competence in at least one (statistical) programming language, such as R, python etc.
Responsibilities
- Perform large-scale genetic analyses on patient cohort data to define nuclear determinants of mitochondrial DNA disease phenotypes
- Perform quality control and data harmonisation for clinical, genetic and environmental data across mitochondrial disease patient cohorts
- Identify individuals who carry mtDNA mutations in large population cohorts such as UK Biobank and 100K Genomes Project and perform large-scale analysis of genetic, phenotypic, environmental and other relevant data within these cohorts
- Collect and collate environmental data from patients and their families through the use of questionnaires, with support
- Lead the experimental planning and co-ordination of above
Requirements
- Knowledge and experience of applying statistical genetic techniques such as GWAS, LMM etc
- Experience of working within a Unix/Linux HPC or cloud computing environment
- Competence in at least one (statistical) programming language, such as R, python etc
- High-level analytical ability with attention to detail
- Ability to work well as part of a team and rapidly acquire new skills
About the Role
This is an exciting opportunity to be part of a team at the forefront of pioneering research from the very start of a project. You will perform large scale analyses of genetic and environmental data to understand how the nuclear genome, environmental factors and mitochondrial DNA mutations interact to drive the development of a wide-range of phenotypes linked to mitochondrial disease.
The position is a fixed-term, full-time post and available for a duration of 3.5 years in the first instance, starting as soon as possible ending on the 30th June 2028.
Benefits
- A competitive salary of £43,000 per annum
- A generous holiday package
- A great pension scheme
- A range of health and wellbeing initiatives
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