Senior Immunologist

We are seeking a highly motivated and experienced Senior Immunologist to join our Cellular Biomarkers Flow Cytometry team within Biomarker & Bioanalytical Platforms in the Precision Medicine department located in the UK.

The successful candidate will have a deep understanding of immunology and will act as a flow cytometry technical expert, supporting high parameter deep immunophenotyping of immune cell subsets as well as receptor occupancy endpoints.

This is a lab-based role and will include all aspects of flow cytometry method development and optimization, validation and sample analysis for clinical studies across the entire GSK portfolio.

The team is responsible for the development and validation of complex multi-parameter flow cytometry panels and subsequent application of these panels to clinical trial sample analysis.

The deep immunophenotyping data generated by these biomarker panels helps us to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses.

The successful candidate will have a PhD in Immunology or a related field with some post-PhD experience in immunology, cell biology, biomedical science, or related disciplines.

Strong immunological knowledge enabling phenotyping of multiple cell lineages with in-depth theoretical and practical understanding of flow cytometry is required.

Considerable experience in the use of flow cytometry analysis software with good attention to detail, excellent oral and written communication skills is also required.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included.

We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

In this role you will:

• Generate high quality data to support clinical studies by spectral flow cytometry (Cytek Aurora)
• Conduct and oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies.
• Handle human biological samples and perform experimental work in accordance with GCP regulations, safety assessments and data integrity guidelines.
• Deliver, interpret and communicate complex scientific data to project/program teams within agreed timelines whilst managing multiple projects concurrently.
• Help lead efforts to investigate novel cytometry and data analysis platforms and embed them within the organisation.
• Function well in a team and possess a good balance of creative and analytical skills. Be willing to develop and train others as required.

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• PhD in Immunology or a related field with some post-PhD experience in immunology, cell biology, biomedical science, or related disciplines.
• Strong immunological knowledge enabling phenotyping of multiple cell lineages with in-depth theoretical and practical understanding of flow cytometry.
• Considerable experience in the use of flow cytometry analysis software with good attention to detail, excellent oral and written communication skills.
• Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, and operational excellence even when flexing between multiple projects.
• Be a highly motivated team player with the ability to interact effectively within a multi-disciplinary team but also the confidence to work independently to tight deadlines.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• A good understanding of the drug development process.
• Experience in design and execution of 22+ colour flow cytometry panels, including receptor occupancy assays.
• Strong laboratory experience and understanding of clinical and non-clinical flow cytometry biomarker assay development, validation and implementation with firsthand practical experience with the Cytek Aurora.
• Direct experience with high-dimensional data analysis (e.g. tSNE, UMAP, CITRUS, FlowSOM).
• Experience of technology transfer of flow cytometry assays to Contract Research Organisations.
• Experience of writing SOPs and other regulated documents.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

We are an Equal Opportunity Employer and we adhere to Affirmative Action principles.

We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

We unite science, technology and talent to get ahead of disease together.