Research Scientist in Biocatalysis

4 weeks ago


Manchester, United Kingdom The University of Manchester Full time
Unlock the Potential of Biocatalytic Therapeutic Oligonucleotide Synthesis

A challenging opportunity has arisen for a Research Associate to join our team at the Manchester Institute of Biotechnology, working under the supervision of Dr Sarah Lovelock. This position involves collaborating with industrial partners, including AstraZeneca, Novartis, CPI, Novo Nordisk, and BioMarin, to develop and optimize a biocatalytic approach to therapeutic oligonucleotide synthesis.

Therapeutic oligonucleotides have emerged as a promising new drug modality for treating various diseases. However, current chemical synthesis methods are not scalable and are limited to small batch sizes. To address this challenge, we are seeking an experienced researcher with a proven track record in biocatalysis and enzyme engineering to join our team.

The successful candidate will have the opportunity to work on a highly interdisciplinary project at the cutting edge of enzyme engineering and nucleic acid therapeutics research. They will have access to state-of-the-art facilities for reaction scale-up and high-throughput automated enzyme engineering, including liquid handling robots, colony pickers, and a suite of high-throughput analytical facilities.

We are looking for a highly motivated and experienced researcher with a PhD or equivalent in Chemical Biology, Biochemistry, or Biocatalysis. The ideal candidate will have a strong background in biocatalysis, enzyme engineering, and process optimization, as well as excellent communication and organizational skills.

As a member of our team, you will enjoy a range of benefits, including a fantastic market-leading pension scheme, excellent employee health and wellbeing services, and exceptional starting annual leave entitlement.



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