Research Scientist

4 weeks ago


Oxford, Oxfordshire, United Kingdom Evox Therapeutic Full time

Job Title: Scientist/Senior Scientist

Company: Evox Therapeutic

Job Summary:

The Research Scientist will play a key role in advancing Genome Editing technology, delivered by exosomes, towards pre-clinical and clinical studies. The successful candidate will apply various loading strategies to deliver Genome Editing therapeutics, contributing to the development of a new class of biotherapeutic products.

Key Responsibilities:

  • Engineer extracellular vesicles to carry gene editing modalities to be delivered to CNS.
  • Perform extensive analysis of the product for quantification of editor/guides using various analytical techniques.
  • Validate the Genome Editor delivery in vitro, using relevant cell lines and analytical tools for the gene editing read-outs (testing uptake, distribution, efficacy, specificity).
  • Identify relevant in vitro models and perform bridging studies to map the translatability of the product from in vitro to in vivo.
  • Analyse, summarise, and document experimental results, as well as being able to communicate them effectively in meetings.
  • Test and troubleshoot new assays and techniques and propose next steps.

Requirements:

  • PhD, MSc, or equivalent experience in molecular/cellular biology, Neuroscience or related biological sciences.
  • Extensive experience in using various cellular models (such as iPSCs), and performing cellular uptake assays (experience with gene editing tools will be advantageous).
  • Strong collaborative and team-oriented mindset.
  • Good conceptual, analytical thinking, problem-solving, and organizational skills.
  • Ability to be self-motivated and work within a fast-paced team environment, achieve deadlines, and be able to prioritize tasks to meet the business needs.
  • Excellent communication & interpersonal skills.
  • Open-minded, with a high level of attention to detail, and dedicated to ensuring quality and compliance are delivered in line with company standards.

Essential Skills:

  • Expertise in cell culture manipulation, maintenance, and transfection, along with molecular characterization of edited cells.
  • Proficiency in molecular biology techniques, including DNA/RNA purification, DNA sequence analysis, PCR, cloning, qPCR, FACS, ICC, and Western blotting.
  • Hands-on experience with gene editing technologies or experience working with extracellular vesicles (EVs).
  • Experience using sequence manipulation software (e.g., Vector NTI, SnapGene).
  • Eagerness to learn and explore emerging scientific fields.
  • Ability to work effectively in a fast-paced, dynamic environment and meet deadlines.

Beneficial Skills:

  • Background knowledge in neuroscience or neurological diseases.
  • Hands-on experience with pre-clinical models in the CNS field.
  • Previous experience in an industry setting.
  • Knowledge of exosome or lipid nanoparticle-based therapeutics.
  • Experience working with iPSC-derived neurons.
  • Familiarity with gRNA design and off-target mapping tools.

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