Research Scientist
4 weeks ago
Job Title: Scientist/Senior Scientist
Company: Evox Therapeutic
Job Summary:
The Research Scientist will play a key role in advancing Genome Editing technology, delivered by exosomes, towards pre-clinical and clinical studies. The successful candidate will apply various loading strategies to deliver Genome Editing therapeutics, contributing to the development of a new class of biotherapeutic products.
Key Responsibilities:
- Engineer extracellular vesicles to carry gene editing modalities to be delivered to CNS.
- Perform extensive analysis of the product for quantification of editor/guides using various analytical techniques.
- Validate the Genome Editor delivery in vitro, using relevant cell lines and analytical tools for the gene editing read-outs (testing uptake, distribution, efficacy, specificity).
- Identify relevant in vitro models and perform bridging studies to map the translatability of the product from in vitro to in vivo.
- Analyse, summarise, and document experimental results, as well as being able to communicate them effectively in meetings.
- Test and troubleshoot new assays and techniques and propose next steps.
Requirements:
- PhD, MSc, or equivalent experience in molecular/cellular biology, Neuroscience or related biological sciences.
- Extensive experience in using various cellular models (such as iPSCs), and performing cellular uptake assays (experience with gene editing tools will be advantageous).
- Strong collaborative and team-oriented mindset.
- Good conceptual, analytical thinking, problem-solving, and organizational skills.
- Ability to be self-motivated and work within a fast-paced team environment, achieve deadlines, and be able to prioritize tasks to meet the business needs.
- Excellent communication & interpersonal skills.
- Open-minded, with a high level of attention to detail, and dedicated to ensuring quality and compliance are delivered in line with company standards.
Essential Skills:
- Expertise in cell culture manipulation, maintenance, and transfection, along with molecular characterization of edited cells.
- Proficiency in molecular biology techniques, including DNA/RNA purification, DNA sequence analysis, PCR, cloning, qPCR, FACS, ICC, and Western blotting.
- Hands-on experience with gene editing technologies or experience working with extracellular vesicles (EVs).
- Experience using sequence manipulation software (e.g., Vector NTI, SnapGene).
- Eagerness to learn and explore emerging scientific fields.
- Ability to work effectively in a fast-paced, dynamic environment and meet deadlines.
Beneficial Skills:
- Background knowledge in neuroscience or neurological diseases.
- Hands-on experience with pre-clinical models in the CNS field.
- Previous experience in an industry setting.
- Knowledge of exosome or lipid nanoparticle-based therapeutics.
- Experience working with iPSC-derived neurons.
- Familiarity with gRNA design and off-target mapping tools.
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