Systems Neuroscience Research Assistant: Therapeutic Development

2 months ago

Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom Newcastle University Full time
About the Role

This position offers an exciting opportunity to contribute to a research project focused on identifying novel disease-modifying therapies for MND/ALS. The successful candidate will be responsible for:

  • Conducting day-to-day research activities, including animal care and training, molecular assays, histology, and data analysis.
  • Collaborating with the research team to achieve project objectives and contribute to the development of new therapeutic approaches.
  • Presenting research findings and progress to the research team and stakeholders.
  • Writing up research results and contributing to the dissemination of project outcomes.
About the Project

The project aims to test compounds that have shown promise in vitro in blocking the pathological effects of mislocalized/aggregated TDP-43. The research will be conducted in a novel macaque model of MND/ALS, which captures the key features of the human disease. The successful candidate will contribute to the development of this model and the testing of potential therapeutic compounds.

Key Accountabilities

The successful candidate will be responsible for:

  • Contribution to the research programme of the School/Institute under the guidance of a member of academic staff or Principal Investigator.
  • Use of initiative and creativity to analyze and interpret research data and draw conclusions on the outcomes.
  • Coordination of own work with that of others, dealing with problems that may affect the achievement of research objectives, and contributing to the planning of the project.
  • Presentation of information on research progress and outcomes to a Principal Investigator or groups overseeing the research project.
  • Writing up results from own research activity and providing input into the research project's dissemination.
  • Work to deadlines and manage competing priorities.
  • Ensure that personal knowledge in relevant fields of study is kept up to date.
  • Use of research resources as appropriate.
  • Maintenance of academic standards and freedom, and work in accordance with university policies.
  • Possible supervision and demonstration duties within undergraduate laboratories and example classes or in teaching small seminar classes.
  • Undertake relevant training and development activities to develop capacity for taking on wider responsibilities.
  • Develop, with advice, an awareness of own professional development needs and a personal development strategy.
Person Specification

The successful candidate will have:

  • Some subject knowledge relevant to neurodegenerative diseases, particularly ALS/MND.
  • Good level of analytical skills, particularly data analysis, and the ability to communicate complex information clearly, both orally and through the written word.
  • The ability to work collaboratively with colleagues as part of a team and to encourage the commitment of others.
  • The ability to use personal initiative and creativity to solve research problems and rapidly acquire new skills.
  • Experience of research with clear transferable skills and some experience or awareness of the research environment.
  • Advanced skills directly related to the research project.
  • Experience of at least 2-3 of the following techniques: behavioural experiments in non-human primates, histology, immunohistochemistry, and mammalian electrophysiology.
Attributes and Behaviour

The successful candidate will possess:

  • Ability to work well in a team.
  • Self-motivated and able to work independently.
  • Good organisational and communication skills.
Qualifications

The successful candidate will have:

  • Good honours degree (2.1 or above) in neuroscience, biomedical sciences, natural sciences, or equivalent, with some subject knowledge in neuroscience.

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