Cellular Toxicologist Specialist

We are seeking an experienced Toxicology Research Scientist Lead to join our team at ENGINEERINGUK. As a key member of our research group, you will be responsible for providing laboratory technical support and utilizing specialist advanced cellular modelling techniques to generate data that helps elucidate mechanisms of toxicity, understand species differences, identify novel translational safety biomarkers, and inform project decisions.

The successful candidate will have a solid background in cell culture and advanced cellular models (such as Complex In Vitro Models, Micro Physiological Systems, and/or Organ on Chip models). They will carry out both paper and laboratory-based studies to support predictive, mechanistic, and translational toxicological investigations across new drug modalities, including Oligos, ADCs, and T-Cell Engagers for projects in discovery and development.

• Independently select, design, and execute innovative investigative toxicology experiments or technical work programs to support Project Issues with minimal supervision; work includes study planning, experiment organization, sample preparation, data generation, processing analysis, and reporting.
• Contribute to the establishment and maintenance of a scientifically current, state-of-the-art laboratory environment.
• Initiate new research directions in cellular toxicology and lead the development of new cellular assay formats/techniques (from tissues, primary cells, or cell culture systems) for the investigation of mechanisms and translation of organ and cellular toxicities and safety risks to the clinic, including routine mammalian cell screening assays.
• Provide high-quality data, acceptable to appropriate principles of data integrity (DI), including quality control (QC) of study data.
• Be a Subject Matter Expert (SME) in your field, with extensive theoretical and technical understanding, and provide expert advice to Project Teams, advisory Safety Panels, Target Safety Reviews, and external partners, etc., as required.
• Understand the disease target under investigation, and if applicable, the therapeutic area, and the programme/project plan and potential safety issues of assigned projects/studies.

We are looking for candidates with:

• A Master's degree or PhD in Cellular biology, Molecular biology, Toxicology, and/or other related biological science.
• Extensive knowledge of and proficiency in the use of multiple advanced in vitro cell model techniques and how to interpret and contextualize data for the purpose of risk assessment, ideally within a Pharmaceutical or Research Institute setting.
• Proficiency in laboratory and in silico techniques to build and implement new human-relevant cell models or other assays to fill strategic gaps and meet Project needs.
• Familiarity with platform data and bioinformatics software and working with data analysts/bioinformaticians to leverage high-content data approaches to support toxicological MOA and risk assessment.

This is an exciting opportunity to join our team and contribute to the advancement of scientific knowledge and innovation. The salary for this role is £80,000 - £110,000 per annum, depending on experience, plus benefits and bonuses.