Senior Scientist/Scientific Investigator

4 weeks ago

Stevenage, Hertfordshire, United Kingdom GSK Full time
Job Description

Job Title: Senior Scientist/Scientific Investigator

Location: UK - Hertfordshire - Stevenage

Job Type: Full-time

About the Role:

We are seeking a highly skilled and motivated Senior Scientist/Scientific Investigator to join our Respiratory Biology team at GSK. As a key member of our team, you will be responsible for designing and delivering advanced biology assays to address key biological questions needed to progress respiratory drug discovery programs across disease indications including COPD and ILD.

Key Responsibilities:

  • Develop and implement respiratory-relevant cell-based assays to evaluate the function of potential drug targets in disease relevant cells via pharmacological modulation and/or genetic manipulation
  • Troubleshoot technical problems relevant to experimental study execution
  • Write protocols, design and execute biology-focused experimental studies, applying advanced data analysis, interpreting data, compiling reports and communicating findings to project teams in order to progress projects and/or develop platforms
  • Build the biological rationale and generate scientific hypotheses to inform experimental design and approaches to support both new target work packages and later stage assets within the respiratory portfolio
  • Work collaboratively in a matrix team and within a cross-functional environment to develop and carry out selected experiments to address key biological questions aligned to project goals within agreed timelines
  • Evaluate potential new targets via in silico-based approaches
  • Maintain a high level of documentation for all experimental work aligned with data integrity expectations

Requirements:

  • PhD or equivalent experience in Respiratory Biology, Cell Biology, Molecular Biology, and/or Immunology
  • Proficiency in designing, executing and interpreting experimental studies across a wide range of laboratory techniques gained from working in industrial or academic research environments
  • Experience of standard laboratory techniques, including cell culture (culture of disease relevant primary or iPSC human cells), optimisation and execution of cell-based assays (phenotypic and mechanistic), molecular biology, RNA isolation, RT-qPCR analysis, protein analysis, imaging and flow cytometric techniques
  • Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner
  • Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards
  • Experience with data analysis software and knowledge of statistical analysis methodology and bioinformatics tools

Preferred Qualifications:

  • Prior experience with establishing disease relevant in vitro models of respiratory disease or in respiratory biology such as human bronchial epithelial culture
  • Good understanding of drug discovery, ability to influence project direction by interpreting results outside area of expertise
  • Track record of scientific innovation as evidenced by effective support of drug discovery projects, peer-reviewed publications, conferences, reports or patents

About GSK:

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Why Work at GSK?

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included.

Equal Opportunities Employer:

GSK is an Equal Opportunity Employer. We are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.* (*US only)

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