Senior Scientist

6 days ago

Cambridge, Cambridgeshire, United Kingdom Regeneron Pharmaceuticals, Inc Full time

**Job Summary**

We are seeking a highly skilled and passionate Senior Scientist to support Regeneron Cell Medicine's mission to bring innovative cell therapy products to patients. This role will be critical to advance TCR- and CAR-based programs, as well as bring new ideas to improve our platforms and future programs.

**Key Responsibilities**

  • Leverage molecular biology techniques to design constructs, clone, and generate lentiviral vectors using proprietary platform technology.
  • Design and carry out experimental plans to functionally characterize TCR- and CAR-based T cell products through cell-based assays and other relevant procedures to explore and validate novel cell therapy approaches.
  • Maintain detailed and timely records of experimental protocols, results, and observations.
  • Identify experimental challenges and collaborate with the team to troubleshoot technical issues and propose creative solutions to overcome obstacles.
  • Stay informed about the latest scientific advancements and apply relevant technologies to improve experimental processes to enhance the efficiency and efficacy of our cell therapy research.

**Requirements**

  • Ability to work effectively in a team-based research environment, exhibiting leadership in the lab on a day-to-day basis.
  • Strong problem-solving skills and capacity to think critically and innovatively.
  • Excellent communication and presentation skills to convey complex scientific information to diverse audiences.
  • Detailed-oriented with a commitment to producing high-quality, reliable data.
  • Excited to support and mentor junior lab members to foster scientific & technical development and ensure experimental excellence.

**Qualifications**

  • Ph.D. in Immunology, Cancer Biology, Molecular Biology, or a related field.
  • 0-3 years of relevant experience or a BS/MS and 8-10+ years of relevant experience.
  • Hands-on experience on LV-vector construct design, cloning, vector production, and mastery of basic molecular biology techniques.
  • Experience with cell-based assays and functional assays measuring T cell activation, cytokine release, proliferation, survival, and tumor cell killing.
  • Experience with standard readouts of tumor coculture (e.g. MSD, Luminex, ELISA, etc.) is a plus.
  • Knowledge of standard TCR/CAR-T cells culture technique is desired.
  • Experience developing and applying complex flow cytometry panels for the characterization of TCR/CAR-T cells preferred.
  • Experience contributing to writing of patents and/or regulatory documents is advantageous.

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