Senior Research Scientist

4 weeks ago

Manchester, United Kingdom Yourgene Health Full time
Job Title: Senior Scientist

About Yourgene Health:

Yourgene Health is a leading integrated technologies and services business, enabling the delivery of genomic medicine. The group works in partnership with global leaders in DNA technology to advance diagnostic science.

The company primarily develops, manufactures, and commercialises simple and accurate molecular diagnostic solutions, for reproductive health, precision medicine and infectious diseases. The Group’s flagship in vitro diagnostic products include non-invasive prenatal tests (NIPT) for Down’s Syndrome and other genetic disorders, Cystic Fibrosis screening tests, invasive rapid aneuploidy tests and DPYD genotyping.

Job Description:

Job Summary:

The Senior Scientist will be responsible for designing, developing, verifying and validating in vitro diagnostic products and services based on next generation sequencing platforms, as well as performing general laboratory maintenance activities.

Key Responsibilities:

  • Execute laboratory operations through the day-to-day planning, execution, analysis, and documentation of experiments to the highest standard with meticulous attention to detail.
  • Contribute to the daily maintenance and running of the laboratory environments.
  • Work collaboratively within teams to create high-quality products and processes meeting key user needs and to ensure a safe and efficient laboratory environment.
  • Provides scientific expertise and technical leadership on projects, as well as planning tactical delivery in functional area.
  • Contribute to overall project planning and reporting as well as leading planning and reporting of defined project work-packages.
  • Lead and participate in activities requiring cross functional collaboration, including leading complex projects.
  • Support the resource planning activities of Team Leaders and Project Leaders.
  • Create, maintain and improve of laboratory SOPs, as well as systems and process SOPs.
  • Lead troubleshooting activities when technical issues arise.
  • Ensure planning and reporting of studies and work-packages is accurate and detailed.
  • Ensuring the quality and regulatory requirements of the role including compliance to SOPs, documentation using electronic lab books, study plans, study reports and integrity of data are met by themselves and the wider team.
  • Excellent organisational skills involved with the management of their own time, working within a team, and the ability to respond to rapidly adjusting situations effectively.
  • Becoming knowledge experts for specific development workflows applications, and diagnostic systems.
  • Perform vital laboratory maintenance tasks alongside the wider team including, equipment usage, purchasing, and stock control tasks to ensure the ongoing and continued functioning of the laboratory environment.
  • Contribute to departmental goals and continuous improvement, potentially aiding in the coordination of improvement initiatives.
  • Supports the identification of commercially and technically useful solutions for development.
  • Support and provide guidance to junior staff.

Qualifications, Skills and Abilities:

  • Degree or further degree (or equivalent) in a life science such as molecular biology, biochemistry or genetics.
  • Typically, 5+ years of relevant experience.
  • Experience in the development, verification and validation of molecular diagnostic assays using NGS technologies in adherence with CE marking and/or design control regulations.
  • Hands on experience with at least two molecular biology-based assays and techniques.
  • Excellent grasp of experimental design and execution and able to lead and train others.
  • Enthusiasm, drive, thoroughness, diligence and a willingness to take personal responsibility to ensure that projects are successful.
  • Strong data analysis and interpretation skills.
  • Ability to think analytically and troubleshoot.
  • Experience with laboratory processes including, processing biological samples, DNA/RNA extraction, library preparation, and Next generation Sequencing.
  • Understanding and experience of multiple NGS platforms including long and short read sequencing technologies.
  • Understanding of sequencing metrics and data analysis.
  • Meticulous scientific technique and attention to detail.
  • Demonstrate accountability.
  • Able to communicate effectively.
  • Ability to work independently and as part of a team.
  • Good organisational skills and enjoys working to tight timelines.
  • Good written and verbal communication skills and ability to document and present work in a clear, consistent, and concise manner.
  • Flexible attitude to work.
  • Demonstrable planning and problem solving skills.

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