Senior Scientist

3 weeks ago

London, Greater London, United Kingdom Proclinical Staffing Full time
Senior Scientist - Upstream Manufacturing

Proclinical Staffing is seeking a highly skilled Senior Scientist to join our team in a hybrid role. This position focuses on the development and optimization of scalable upstream manufacturing processes, particularly involving bioreactors and viral vectors.

Key Responsibilities:
  1. Bioreactor Operations: Independently and collaboratively set up and handle bioreactors for manufacturing research/nonclinical grade viral vectors and recombinant proteins using mammalian cell suspension systems.
  2. Process Development: Lead the development and implementation of methods and protocols for upstream manufacturing processes.
  3. Data Analysis and Quality Control: Execute, analyze, quality control, and present data within the scope of work.
  4. Scientific Experimentation: Design, execute, and document scientific experiments with high quality and timeliness.
  5. Project Management: Provide project summaries and reports, adhering to established quality standards and accurate record-keeping.
  6. Knowledge Transfer: Ensure knowledge transfer and training of junior staff and colleagues.
  7. Collaboration: Collaborate with the internal CMC team for the transfer of manufacturing and quality aspects from Research to CMC.
  8. External Collaboration: Support work involving external collaborations and Contract Development & Manufacturing Organizations (CDMOs).
  9. Technology Evaluation: Source, develop, and evaluate technologies and processes for AAV batches to improve yield, quality, and impurity profiles.
  10. Analytical Monitoring: Familiarity with biochemical analytical monitoring of bioreactors.
  11. Scientific Accomplishments: Evidence of scientific accomplishments through publications and presentations.
  12. Critical Thinking: Strong critical, scientific, and strategic thinking skills.
  13. Data Presentation: Experience in interpreting and presenting data to stakeholders.

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