PKPD Research Scientist
4 weeks ago
The CK Group is seeking a highly skilled PK/PD Scientist to join their team in Bracknell. This contract-based position offers a unique opportunity to contribute to high-impact research endeavors in the pharmaceutical industry.
Key Responsibilities:
- Develop and apply advanced research and communication skills to drive research endeavors in discovery to advanced clinical development of Antibody Drug conjugates (ADC).
- Elaborate the appropriate dose and regimen to achieve better therapeutic index and understand preliminary dosing requirements.
- Establish a comprehensive and flexible framework (Clinical Utility Index) for modeling ADC PKPD and the Exposure-Response relationship in both preclinical and clinical settings.
- Design a cellular mathematical model with a deep understanding of physiochemical properties, the range of affinities that are compatible with the target product profile for each ADC target, and the mechanism of action of ADC components (mAb, linker and payload and conjugated ADCs).
Requirements:
- PhD in Pharmacometrics, Pharmaceutical/Biomedical Sciences, Computational Sciences, Engineering, or a related discipline.
- Experience using relevant software such as R, Monolix, NONMEM, MATLAB, or similar.
- Experience in QSP, PK/PD, exposure-response modeling or other modeling & simulation related discipline.
- Understanding of pharmacokinetics and/or pharmacodynamic principles.
- Proficient in data analysis and reporting.
About the Company:
The CK Group is one of the largest pharmaceutical companies in the world, dedicated to finding answers for some of the world's most urgent medical needs. This role is based at their site in Bracknell, with a hybrid work arrangement requiring office presence two times per week. The ideal candidate will have a strong background in pharmacometrics and modeling, with excellent communication and research skills. If you are passionate about contributing to cutting-edge research in the pharmaceutical industry, please apply for this exciting opportunity.
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