Scientific Researcher

1 month ago

Worcester, Worcestershire, United Kingdom AbbVie Full time
Job Description

AbbVie is seeking a highly skilled Senior Scientist I to join our team in the development of innovative medicines and solutions. As a key member of our scientific team, you will be responsible for developing, optimizing, and executing new analytical methods and techniques to characterize complex proteins, glycoproteins, antigens, and novel protein-based therapeutics.

Key Responsibilities
  • Develop and optimize new analytical methods and techniques to characterize complex proteins, glycoproteins, antigens, and novel protein-based therapeutics.
  • Work within multi-disciplinary project teams and act as a lead analytical and biophysical resource to guide development and advance pipeline.
  • Resolve key project challenges by effectively utilizing available analytical tools, information, and technical expertise.
  • Develop, optimize, and execute new analytical methods and techniques to characterize complex proteins, glycoproteins, antigens, and novel protein-based therapeutics.
  • Strategically advance scientific expertise within the Analytics group by conceiving and executing novel scientific research and development efforts to address project challenges and provide novel insights.
  • Demonstrate leadership by advising and sharing knowledge and expert opinions with peers and senior management.
  • Contribute to research that leads to peer-reviewed publications, reports, and external presentations.
  • Employ experience in protein analytical and biophysical characterization to discern protein critical quality attributes (physiochemical properties, post-translational modifications) and better understand protein structure-function relationships.
  • Work in cross-functional teams with scientists across functions and therapeutic areas (Virology, Immunology, Oncology, and Neuroscience) to discover and develop next-generation biologics through interrogation and engineering of protein attributes across both targets and therapeutic molecules.
  • Responsible for utilizing verbal and written skills and the ability to clearly present scientific concepts and results for functional scientific and non-scientific leaders.
  • Employ experience with in-depth protein analytical characterization using a variety of techniques such as LC-MS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF.
  • Employ experience utilizing various software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, and ImageJ.
  • Responsible for demonstrating proficiency with various chromatographic techniques, capillary electrophoresis methodologies, and in-depth biophysical characterization.
  • Responsible for preparation and characterization of disease-relevant proteins in defined morphological states. Employ experience in guiding recombinant protein expression and purification.
  • Employ experience with protein labeling and conjugation, as well as protein formulation and remediation. Prepare written documentation, reports, and presentations of work and strategies.
  • Work on the selection of targets or variants for therapeutic development and include the design, engineering, and characterization of resulting therapeutics and their mechanisms of action.
  • Employ experience with routine mass spectrometry workflows, including intact and subunit analysis.
  • Responsible for project-driven initiatives that will require scientific exploration and experimentation as well as close collaboration with scientists across the organization.
  • Responsible for new technology development by expanding analytical expertise and custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering and developing novel therapeutics.

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