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Senior Scientist

2 months ago

Stevenage, Hertfordshire, United Kingdom GlaxoSmithKline Full time
About the Role

We are seeking a highly skilled and motivated Senior Scientist to join our Antibody Engineering team within the Molecular Design and Engineering (MDE) group at GlaxoSmithKline. As a key member of our team, you will be responsible for working on the discovery and development of innovative biopharmaceutical medicines, with a focus on antibody engineering and developability profiling.

Key Responsibilities
  • Antibody Sequence and Structure Analysis: You will analyze antibody sequences and structures to identify potential liabilities and design de-risked variants.
  • Strategic Recommendations: You will provide strategic recommendations for molecule engineering, humanization, and de-risking to program teams.
  • Innovative Engineering Strategies: You will develop and explore innovative engineering strategies to create evolutionarily plausible variants with strong developability profiles.
  • Cloning and Sequencing: You will clone antibodies, bispecifics, and other advanced formats into expression vectors, followed by sequencing and upscaling the generated plasmids.
Requirements
  • Graduate or Postgraduate Degree: You must have a graduate or postgraduate degree in Molecular Biology, Biochemistry, Biotechnology, or a related discipline.
  • Experience in AI and Protein Modeling: You must have experience in applying AI to protein sequence, structure, and experimental data, particularly in the context of drug/biologic design and engineering.
  • Protein Modeling and Interpretation: You must have experience in protein/antibody modeling and interpretation of the structure data.
  • Molecular Biology and Protein Design: You must have basic skills in molecular biology, protein design and engineering, DNA cloning, preparation, upscaling, and analysis of sequencing results.
Preferred Qualifications
  • Established Experience in Antibody Discovery: You must have established experience in antibody discovery and/or design, with a broad scientific understanding of the relationship between antibody sequence/structure and function.
  • Bispecifics and Advanced Antibody Formats: You must have basic experience or knowledge about bispecifics and other advanced antibody formats.
About GlaxoSmithKline

GlaxoSmithKline is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology).