Regulatory Chemist

1 month ago

London, Greater London, United Kingdom Merck Gruppe - MSD Sharp & Dohme Full time
Job Title: Senior Scientist Protein and Structural Chemistry

We are seeking a highly motivated Senior Scientist to join our growing London Discovery Protein and Structural Chemistry team based in the Francis Crick Institute in London.

This laboratory-based role is integral to our mission to use the power of leading-edge science to save and improve lives around the world. Successful candidates will support drug discovery with atomic resolution macromolecular single particle CryoEM and X-ray crystallography to determine the structures of therapeutically important drug targets to accelerate the discovery of new medicines.

Key Responsibilities:
  • Responsible for all aspects of the experimental process from sample preparation and data collection through data processing, structure determination.
  • Communicate effectively with all key stakeholders with the results of structural analyses.
  • Proactively participate in collaboration with colleagues in Modelling & Informatics, Discovery Chemistry, Screening and Compound Profiling, and Mass Spectrometry and Biophysics.
  • Identify and manage internal and external scientific partnerships, as necessary.
  • Active interaction with the external scientific community to continually improve scientific understanding, including presentations at external meetings.
Requirements:
  • Demonstrated experience in a broad range of activities for X-ray crystallography, including crystallisation screening and optimisation, crystal harvesting, data collection, and structure determination.
  • Demonstrated experience in a broad range of activities for atomic resolution single particle CryoEM, including sample preparation, data collection, image processing and structure determination.
  • Excellent written and oral communication skills that enhance team-based progress and application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management.
  • Experience with scientific programming (e.g. Python) and interest in the application of computational tools to answer structural biology questions.
  • Ability to manage multiple projects and subsequent prioritisation.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

Employee Status: Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements: Not Applicable

Shift:

Valid Driving License:

Hazardous Material(s):

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