Director of Respiratory and Immunology Modelling and Simulation

1 week ago


Stevenage, Hertfordshire, United Kingdom VONQ Full time
Job Title: Director of Respiratory and Immunology Modelling and Simulation

We are seeking a highly skilled Director of Respiratory and Immunology Modelling and Simulation to join our team at VONQ. As a key member of our Clinical Pharmacology Modelling and Simulation department, you will play a critical role in driving the integration of end-to-end model-informed drug discovery and development.

Key Responsibilities:
  • Establish and guide mathematical model development to understand disease progression and drug action.
  • Define and execute a coordinated scientific and technical strategy with demonstrated ability to coordinate outputs from multiple expertise areas.
  • Build and utilize mechanistic models of biological, physiological, and pathophysiological processes to evaluate disease mechanisms and drug candidates.
  • Collaborate with bench biologists, data scientists, computational biologists, clinicians, and other partner line colleagues to inform research and development programs.
  • Develop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of system-level and drug-level responses.
  • Create a collaboration framework with internal and external experts in the development and application of these models.
  • Implement best practices, trends, and lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline.
Requirements:
  • PhD, MD, or PharmD with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development.
  • Significant experience in clinical pharmacology, modelling/simulation and drug development to solve practical problems in pharmaceutical industry.
  • Significant experience in mechanistic mathematical modeling and the application of such to clinical questions in drug development.
  • Experience in the respiratory therapy area.
Preferred Qualifications:
  • Additional experience in immunology would be beneficial.
  • Demonstrated experience of collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results.
  • Evidenced experience making sound judgement in complex situations and adapt to changing business needs by prioritizing multiple tasks.
  • Experience working with senior stakeholders in a cross-functional environment.
  • Strong track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.
  • Strong drive and learning agility to build knowledge on a drug-disease system, symptom progression, standard of care, and trial design.


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