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Building Scientist

2 months ago

Oxford, Oxfordshire, United Kingdom Nucleome Full time
Job Description

Company Overview

Nucleome Therapeutics is a fast-growing biopharmaceutical company dedicated to decoding and mining the regulatory "dark matter" of the human genome to transform drug target discovery and deliver first-in-class precision medicine for autoimmune diseases.

Job Summary

We are seeking a talented scientist with a background in cellular pharmacology in primary immune cells to support the progression of early biologics drug targets emerging from our proprietary platform technology.

Key Responsibilities

  • Develop primary and secondary assays for evaluation of early biologics drug molecules
  • Engage in mechanism of action studies
  • Support the progression of multiple asset programmes in early drug discovery
  • Develop assays to test therapeutic hypotheses
  • Investigate the pharmacology of tool and candidate molecules
  • Characterise the biological impact of drug molecules in 'on target' and 'off target' cell types

Requirements

  • Good understanding of the principles of cellular immunology and pharmacology
  • Understanding of principles of cellular assay optimisation
  • Ability to design, execute, and analyse cellular pharmacology experiments in primary immune cells independently
  • PhD qualification in a relevant field (e.g., immunology, autoimmunity, or immuno-oncology) together with experience within a biopharma or academic setting or equivalent work experience within biopharma
  • Direct practical experience in conceiving, developing, and performing multi-parameter flow cytometry, ELISA (ideally a multiplex system)
  • Experience of analysing and presenting data using FlowJo and GraphPad Prism software
  • Strong communication skills and ability to communicate complex ideas to specialists and non-specialists
  • Flexible and co-operative approach to colleagues
  • Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects
  • Strong organisational and time management skills to work on multiple projects simultaneously
  • Ability to deliver high-quality, consistent results in a timely fashion
  • Research experience in an immunological disease therapeutic area
  • Proficiency in laboratory techniques including Western blotting, immunohistochemistry, and/or qPCR
  • Experience in genetic manipulation assays CRISPR or RNA knockdown

What We Offer

Nucleome Therapeutics is an equal opportunities employer and welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.