Research Scientist

4 weeks ago

Manchester, United Kingdom Morson Talent Full time

Job Title:
Research Scientist

Starting Salary:
Approximately GBP25,000 (dependent upon experience)

Duration:
Fixed term contract

Location:
Manchester

About the Role:
We are seeking a Research Scientist to become a part of our National Biomarker Centre.

The National Biomarker Centre (NBC) at CRUK Manchester Institute is at the forefront of cancer biomarker research.

The NBC comprises several synergistic teams, including the Preclinical Pharmacology (PP) team, which employs various preclinical cancer models to explore the biology and dependencies of diverse cancers.

A key aspect of this role involves the creation, development, and application of animal models of cancer, particularly focusing on patient-derived models.

The objective of this position is to assist in the daily operations of the preclinical team and conduct research under the guidance of the Group Leader, Preclinical Pharmacology Team Leader, and In Vivo Team Manager.


About You:

You should possess a BSc (or equivalent) in a biology-related field or have relevant experience, and be a current or former holder of a Home Office Personal Licence (PIL A and B) or equivalent under the Animals (Scientific Procedures) Act 1986.

Your responsibilities will include conducting in vivo preclinical pharmacology studies in collaboration with academic and industrial drug developers, including the analysis of predictive and pharmacodynamic biomarkers.

Ideally, you will have foundational knowledge of cancer biology, experience in in vivo pharmacology, and a strong commitment to translating research for patient benefit.

Our Centre is dedicated to discovering, developing, validating, and qualifying biomarkers in clinical studies and trials that facilitate earlier cancer detection and optimize treatment responses.

Our advanced research initiatives, independent of cancer type, focus on developing biomarkers in tissue and less invasive clinical samples such as blood (liquid biopsy), utilizing sophisticated bioinformatics and artificial intelligence solutions for comprehensive laboratory and clinical biomarker data analysis and interpretation.

Our preclinical programs emphasize the development of pharmacodynamic biomarkers and the evaluation of novel therapeutics in patient-derived models.

As a vital link between discovery science and clinical research, we maintain a highly collaborative environment across Manchester, nationally, and internationally.

Organisational Arrangements

Day to Day:
I. NBC Preclinical in vivo team leader

Accountable to:
I. NBC Preclinical in vivo team leader
II. NBC Preclinical Pharmacology Team Lead
III. NBC Group Leader

Job Purpose

To conduct in vivo research within the Preclinical Pharmacology team at the National Biomarker Centre, primarily focusing on research involving lung cancer mouse models.

The successful candidate will collaborate with team members to generate and maintain preclinical mouse models of human cancer and may also participate in evaluating the models' responses to therapy.



Duties and Responsibilities

Utilizing established protocols and procedures, and with in-house training as necessary, plan and execute your work after consultation with the Preclinical in vivo Team Leader. All tasks will comply with the Animal (Scientific Procedures) Act 1986.

The post holder will:

  • Be expected to hold a Home Office Personal Licence and operate in accordance with the Animal (Scientific Procedures) Act 1986.
  • Prepare patient samples (typically blood or tumour tissue) for in vivo use.


  • Conduct in vivo work, including implanting cells for xenograft studies or patient tumour tissue for PDX studies, administering drugs, monitoring tumours (which may involve occasional weekend work), performing surgical procedures, and conducting clinical observations.
  • Utilize automated data collection and study conduct software to accurately document all in vivo study details.
  • Be responsible for all aspects of in vivo work from DISCO Therapeutics Collaboration.
  • Perform ex vivo processing and analysis of xenograft tumour samples and circulating biomarkers.
  • If necessary, conduct in vitro experiments (e.g., cell culture, drug treatment, western blotting) initially under close supervision, with increasing independence as competence is demonstrated.
  • Stay updated on literature relevant to current projects.
  • Present findings at team/group meetings and journal clubs.
  • Work efficiently, cost-effectively, and flexibly.
  • Share knowledge of techniques and procedures for the benefit of others.
  • Provide expert advice and guidance to colleagues.
  • Contribute significantly to the overall success of the group.
  • Undertake any other duties as requested by the NBC Preclinical in vivo team leader.
  • Ensure all regulatory tasks and training are completed promptly to avoid backlogs.

Standards of Performance

  • Work efficiently, cost-effectively, and flexibly.
  • Meet objectives within predetermined timelines.
  • Maintain effective communication with staff at all levels.
  • Adhere strictly to protocols and Institute policies.
  • Comply with Health & Safety requirements, including awareness of personal responsibilities to maintain a safe working environment.
  • Contribute to the University’s agenda for social responsibility, including sustainability.
  • Maintain confidentiality of information in line with data protection requirements and University policy.
  • Familiarize yourself with the University’s Equality and Diversity policies and actively support these wherever possible.
  • Be a team player.
  • Strive to achieve high-quality work.
  • The post holder will be required to receive a Hepatitis B vaccination if not already immunized.
  • Complete a security check screening as required.

Person Specification

The person specification outlines the qualifications, experience, skills, knowledge, personal competencies, and other requirements necessary for the post holder to perform the job satisfactorily.



Job Title:
Research Scientist

Essential
The qualities without which a post holder could not be appointed.
Desirable
Additional qualities that can be used to differentiate between candidates who meet all essential criteria.
Method of Assessment

Qualifications

  • BSc (or equivalent) in a biology-related discipline or equivalent relevant experience.
  • Completed Home Office Personal Licence Modular Training for PIL C or equivalent under the Animals (Scientific Procedures) Act 1986.


  • Current or previous holder of a Home Office Personal licence (PIL A and B) or equivalent under the Animals (Scientific Procedures) Act 1986.


Experience

  • Relevant experience working in a laboratory setting.
  • Some experience in cancer research and/or pharmacology.


  • Relevant experience working with rodent in vivo models, preferably mice.
  • Some experience with mouse models of cancer.
  • Some knowledge of the principles of good laboratory practice (GLP).
  • Some experience of collaborating with clinical colleagues.

Skills

  • Creative thinking regarding key scientific issues.
  • Strong experimental/technical skills.
  • Ability to plan experiments and interpret results after discussion with the line manager.
  • Accurate and comprehensive record-keeping with attention to detail.
  • Effective communication skills, both written and verbal.
  • Strong organizational skills and good multitasking ability.
  • Problem-solving capabilities.
  • Ability to work well within a team framework as well as independently on projects.
  • Ability to make intellectual and practical contributions to projects.
  • Previous experience with surgical procedures.
  • Familiarity with Studylog software or other automated data collection software designed for in vivo applications.

Knowledge

  • Some knowledge of cell biology.
  • Proficient in basic computing software (e.g., MS Office).
  • Understanding of cancer biology and pharmacology.

Other

  • Self-motivated.
  • Collegiate and forward-thinking.
  • Meticulous.
  • Interactive.
  • Technically focused.
  • Willingness to learn and implement new management and experimental techniques.
  • Hepatitis B vaccination.

Other (contd)

  • Commitment to equality, fairness, and integrity in dealing with others.
  • Willingness to work across organizational boundaries.
  • Eagerness to seek new knowledge and share ideas.
  • Openness and responsiveness to change and innovation.

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