Rna Synthesis Senior Scientist

2 days ago


Cambridge, United Kingdom Hays Specialist Recruitment Limited Full time

We are currently seeking an RNA Synthesis Senior Scientist who will join the Cell Culture & Fermentation Sciences team, a team who are responsible for generating recombinant proteins and novel drug modalities to support internal projects at all stages ofDrug Discovery. The team is responsible for the development of exciting new technologies around mRNA/saRNA, viral vectors and rapid protein expression.
Main Responsibilities:

- Key contributor to the establishment of a high yielding and high-quality scalable mRNA and saRNA production process
- Develop robust and scalable in vitro transcription process using DoE principles
- Hands-on contribution to drug design, screening, optimisation, and scale-up efforts for mRNA/saRNA synthesis
- Hands-on contribution to generation of high-quality preclinical grade mRNA/saRNA material
- Leading and contribution to technology development activities around the production of novel drug modalities including new generation RNA synthesis processes
- Supporting laboratory activities within Cell Culture and Fermentation Sciences including rapid recombinant protein production using transient expression systems and contribution to general laboratory troubleshooting
- Maintain high quality documentation of results in electronic lab notebooks and draft protocols as required.
- Generate clear and appropriate reports according to project requirements.
- Ensure work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g., Good Laboratory Practice (GLP)

Qualifications & Experience:

- BSc/ PhD in Life Science - Biotechnology, Molecular Biology, Biochemistry, Chemical Engineering or other relevant scientific field, with proven relevant experience in the Life Science industry
- Biopharmaceutical process development including mRNA/saRNA synthesis
- Optimising in vitro transcription and RNA production technologies.
- Molecular/cell biology techniques such as PCR, plasmid production/processing, DNA template design, DNA sequencing data analysis and alignment
- Bioreactor process scale up and scale down models for nucleic acid synthesis
- Knowledge of enzyme kinetics and standard analytical techniques for macromolecules

Desirables:

- Mammalian cell culture and recombinant protein expression from mammalian cells in an industrial and/or academic environment
- Experience in using transient expression platforms for rapid recombinant protein expression
- Experience in stable expression systems
- Experience working with bioreactor systems for mammalian cell culture



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