Research Associate
2 weeks ago
Job id: 085872. Salary: £43,205 per annum, including London Weighting Allowance.
Posted: 06 March 2024. Closing date: 26 March 2024.
Business unit: Faculty of Life Sciences & Medicine. Department: Department of Infectious Diseases.
Location: Guy's Campus. Category: Research.
Back to job search
The Odendall Laboratory studies both sides of interactions between the host and enteric bacterial pathogens. We seek to understand the interplay between the bacteria _Salmonella_ and _Shigella_ and type I and III interferons (IFNs).
Type I and III IFNs are induced, along with other cytokines, upon detection of microbes. They have a direct effect on the tissue, inducing hundreds of interferon-stimulated genes (ISGs), with diverse antimicrobial functions. While the functions of type I/III IFNs in antiviral immunity are extensively studied, if/how IFNs and their ISGs protect against bacterial infection is poorly understood.
We have recently reported that bacterial factors translocated by the _Shigella_ type III secretion system (T3SS) block IFN receptor signalling (Alphonse et al, Cell, 2022), and the induction of ISGs. This suggests the importance of this pathway in host defence against bacteria. Indeed, IFNs were protective against _Shigella_ infection in cellular and animal models of infection.
Similarly, we have found that IFN restricted intracellular infection with _Salmonella_, an enteric pathogen with similarities to _Shigella_. This MRC-funded project will investigate the functions of type I/III IFNs and a few key ISGs in mouse models of _Salmonella_ infection.
Mice lacking IFN receptors will be infected with different strains of _Salmonella_. _Salmonella_ pathogenesis and the immune response to infection will be investigated, including histopathological scoring, and gene expression studies.
This post will be offered on an a fixed-term contract until February 2026.
This is a full-time post.
Key responsibilities
Develop a cutting-edge research project aiming to identify the functions of type I and III IFNs in mouse models of _Salmonella_ enterocolitis
Communicate research findings via drafting of publications arising from this work; and preparation and delivery of presentations about relevant research findings within the team and within and outside of the Department.
Handle laboratory equipment safely and considerately, assist with general laboratory upkeep, report safety issues instantaneously, and comply with the requirements of the Health and Safety regulations.
Contribute to the day-to-day training and supervision of junior staff and undergraduate and/or graduate students within the Team (as appropriate)
Initiate purchase of consumable items and minor equipment within budgetary limits and in consultation with the PI.
Positively support equality of opportunity and equity of treatment to colleagues and students in accordance with the College Equal Opportunities policy
- The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post._
Skills, knowledge, and experience
Extensive experience in immunology and mouse models of infection will be required
Essential criteria
- Expertise with mouse models
- Expertise with flow cytometry, imaging, histopathological scoring
- Experience with tissue culture
- Academic integrity and rigor
- Ability to work both collaboratively and independently
- Excellent communication skills
- Excellent note-keeping skills
- Honest and accurate reporting
- Experience supervising students
Desirable criteria
- Experience with bacterial infection models
- Microbiology expertise
- Expertise in molecular biology/biochemistry
Further Information
Applicants should include a CV and a Cover Letter, outlining their suitability for the post and how they meet the Essential/Desirable criteria.
-
Associate Director
1 day ago
London, United Kingdom Research Partnership Full timeWe invite you to come grow with us. Research Partnership (part of Inizio Advisory) is one of the world's largest pharma market research and consulting agencies with over 250 researchers, consultants, project managers and support staff. Our teams are located across the globe, in Europe (London, Lyon), North America (New York, Philadelphia, San Francisco) and...
-
Research Associate
3 weeks ago
London, United Kingdom BCNO Group Full timeHours: 35 hours pw, full time About Us The BCNO Group brings together two well-renowned osteopathic educational institutions – the European School of Osteopathy and the British College of Osteopathic Medicine. Our Research team, led by Dr William Gowers, focuses on providing high-quality support for undergraduate and institutional research...
-
Research Associate
3 weeks ago
London, Greater London, United Kingdom BCNO Group Full timeHours: 35 hours pw, full time About UsThe BCNO Group brings together two well-renowned osteopathic educational institutions – the European School of Osteopathy and the British College of Osteopathic Medicine. Our Research team, led by Dr William Gowers, focuses on providing high-quality support for undergraduate and institutional research activities within...
-
Biomedical Research Associate
3 weeks ago
London, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562) A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Biomedical Research Associate
3 weeks ago
London, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562) A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Biomedical Research Associate
3 weeks ago
London, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562)A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Biomedical Research Associate
1 week ago
London, United Kingdom Centre People Appointments Full timeJob DescriptionBiomedical Research Associate (MY45562)A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from...
-
Research Associate
5 days ago
London, United Kingdom BioTalent Full timeTitle: Clinical Research Associate Location: Hybrid- London Hourly Rate: Competitive Contract Type: 6 months CRA being appointed to secure sample forecast, assist with monitoring on the study and data cleaning as well as support with due diligence monitoring on the first in human programme (FiH). Project Overview and Objectives Support the...
-
Graduate Research Associate
1 month ago
London, United Kingdom Graduate Recruitment Bureau Full timeThis leading, global executive search firm have offices spanning the globe (USA, Sydney, Hong Kong and many more) and recruit into a number of practices including the arts, non-profits and research and development. The current demand is for a graduate research associate in the schools practice. They work with the UK's leading schools, helping them to source...
-
Biomedical Research Associate
3 weeks ago
London Area, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562)A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Biomedical Research Associate
3 weeks ago
London Area, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562) A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Biomedical Research Associate
3 weeks ago
London Area, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562)A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Biomedical Research Associate
3 weeks ago
London Area, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562)A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Research Associate
3 weeks ago
London, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562) A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Research Associate
3 weeks ago
London, United Kingdom Centre People Appointments Full timeBiomedical Research Associate (MY45562) A fast-growing biotech start-up is looking for a Biomedical Research Associate to join their research team in London. The company’s focus is on technological development of reproductive cells with iPS and ES cells. This is an amazing opportunity for those looking to join the commercial industry from academia and...
-
Research Associate
3 weeks ago
London, Greater London, United Kingdom King's College London Full timeJob DescriptionWe seek a talented, highly motivated and independent Postdoctoral Research Associate (fixed-term) to study antibody structure and function at King's College London. Work will be carried out in the laboratory of Professor James McDonnell in the Randall Centre for Cell and Molecular Biophysics within the Faculty of Life Sciences and Medicine at...
-
Clinical Trials Associate
4 weeks ago
London, United Kingdom Hammersmith Medicines Research Full time**Clinical Trials Associate and training leading to a** **University Certificate in Clinical Pharmacology Practice** North West London **Starting salary £27,500** with structured 6-monthly reviews rising to **£30,000 **in **6 months** and **£36,500 **in **2 years** + estimated £2,000 for unsocial hours We are an independent contract research...
-
Research Associate
6 days ago
London, United Kingdom Castleforge Partners Full timeCastleforge is an entrepreneurial research-led private equity real estate fund manager. Founded in 2010, we currently manage two fully discretionary funds backed by institutional investors in the US, UK and Europe and have c. £800 million of office, private rented residential and hotel assets under management in London, UK regional cities and in Europe...
-
Research Associate
3 weeks ago
London, Greater London, United Kingdom Queen Mary University of London Full timeAbout the RoleApplications are invited for a fully funded position at the Research Associate level within the Centre for Advanced Robotics (ARQ), School of Engineering and Material Sciences at Queen Mary University of London. The project is funded by NERC, under the supervision of Dr. Ketao Zhang and Dr. Paul Balcombe. The project will investigate...
-
Research Associate
1 day ago
London, United Kingdom King's College London Full timeJob id: 089667. Salary: £43,205 per annum, including London Weighting Allowance. Posted: 16 May 2024. Closing date: 30 May 2024. Business unit: Faculty of Life Sciences & Medicine. Department: Department of Infectious Diseases. Location: Guy's campus. Category: Research. Back to job search About Us: About the role: About You: Essential criteria -...