Research Associate in Evolving Quantum Mechanical

5 months ago

Manchester, United Kingdom The University of Manchester Full time

Applications are welcomed for this 36 month post based in the Manchester Institute of Biotechnology (MIB) and Department of Chemistry at The University of Manchester. The post aims to map QMT contributions to enzyme reactions along artificial enzyme evolutionary trajectories. This approach will involve the development and use of laboratory DE strategies, advanced enzyme kinetics, kinetic isotope effect (KIE) measurements and structural biology. You will work in the research groups of Professor Sam Hay and Professor Anthony Green, which are currently funded by the BBSRC, EPSRC, ERC and other sources, and are well-equipped for a full range of computational, molecular and biophysical techniques.

**Overall Purpose of the Job**

During the project you will design the methodology for, and perform the directed evolution of H-transfer enzymes using parallel selection methods, measure enzyme activity, kinetics and isotope effects, and potentially perform X-ray crystallography experiments.

Prior experience in the directed evolution of enzymes and/or the measurement of kinetic isotope effects (KIEs) on enzyme catalysed reactions is essential, and experience of high-throughput chromatography is highly desirable. Experience in one or more of the following areas would be an advantage:

- X-ray crystallography
- Computational chemistry

**What you will get in return**:

- Fantastic market leading Pension scheme
- Excellent employee health and wellbeing services including an Employee Assistance Programme
- Exceptional starting annual leave entitlement, plus bank holidays
- Additional paid closure over the Christmas period
- Local and national discounts at a range of major retailers

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Our University is positive about flexible working - you can find out more here

Hybrid working arrangements may be considered.

**Enquiries about the vacancy, shortlisting and interviews**:
Name: Professor Sam Hay

**General enquiries**:
**Technical support**:
**Please see the link below for the Further Particulars document which contains the person specification criteria.

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