Genetic Technologist

2 months ago

London, United Kingdom Synnovis Full time

We are seeking an enthusiastic Genetic Technologist to work in The Laboratory for Molecular Haemato-Oncology (LMH) which provides a wide repertoire of molecular investigation to the King’s Haematological Malignancy Diagnostic Service (SE-HMDS) within the South East NHS Genomic Laboratory Hub (GLH), through identification and quantification of molecular variants/markers for diagnostic, prognostic and monitoring purposes. You will be working closely with clinical teams as well as other laboratories that make up the SE-HMDS, including immunophenotyping, cytogenetics.

You must have substantial experience in a molecular diagnostics setting. Excellent communication skills and a strong self-directed work ethic are essential. The primary role will be performing next-generation sequencing using customised gene panels for variant detection, variant analysis and reporting, and being responsible for maintaining an efficient day-to-day NGS service. Development and validation of new tests, to maintain compliance with the National Test Directory, will also be part of this role.

As part of the LMH team, when needed, the post holder will also carry out other tests or processes, which may include sample preparation, disease monitoring by qPCR, fragment analysis, as well as aspects of Quality management, such as carrying out audits. You must be flexible in terms of the working day, due to the sometimes unpredictable challenges of maintaining a high-intensity service.

The post holder will be responsible for delivering a high-quality service covering a range of specialised investigations. The role involves data analysis, result evaluation, interpretation and reporting of haematological malignancies, ensuring work is carried out to a high standard and within relevant target reporting times.

Primary responsibility of the role will be to run and maintain the NGS service, using custom panels. This will involve both performing the tests, as well as day-to-day management of the service. This includes the use and maintenance of Hamilton liquid handling robots, stock control, trouble shooting, and training of staff and liaising with companies who provide reagents and equipment.

The improvement and development of the NGS service is part of the role, which involves assisting with development of new tests, formulating experimental protocols, performing validations and SOP writing, all of which will require a strong aptitude for data analysis, including the use of Excel.

As part of a fast-paced LMH service, the post holder will, when needed, also perform other molecular investigations including qPCR and fragment analysis. For efficient operation of the laboratory, staff may be required to assist with processing clinical samples, maintain laboratory equipment and general clerical and administrative duties. Occasional flexibility in working hours may be needed, with time off in lieu. Good communication, team working and supervisory skills are essential.

You will have a suite of learning opportunities available through The Synnovis Way Development programme, the Scientific Learning and Development Fund and the Synnovis Academy through which you can receive funding / support for advanced qualifications.

We will assist you to maintain a portfolio that demonstrates CPD achievement and is compliant with the requirements of ongoing HCPC registration. We support flexible working patterns and remote working for activities that can be performed off-site to promote a healthy work/life balance.
Technical and Scientific
- To be able to undertake activities requiring prolonged concentration and attention to details in accordance with Standard Operating Procedures (SOP’s) and Health and Safety Regulations.
- Undertake training and development to successfully acquire core competencies necessary for performance as a Genetic Technologist and thereafter maintain the required standards of competence
- The primary responsibility of the role will be to undertake Next Generation Sequencing (NGS) using Haemato-Oncology targeted panels, including:

- To carry out the laboratory tests for NGS assays, which includes the use of liquid handling robots
- to carry out analysis and interpretation of DNA variant data using a range of software tools
- to prepare reports ready for authorisation
- to ensure work is carried out to a high standard and within relevant target reporting times.
- The role will also be to assist in the development and implementation of new NGS or other tests under the direction of senior staff. They will be expected to write new Standard Operating Procedures (SOPs) as necessary, and review/update existing SOPs on a regular basis using the laboratory document management system.
- Additionally, other tests will be performed when required, according to individual competencies, which may include, but are not restricted to, RT-PCR, fragment analysis and SNP array.
- Contribute to a comprehensive diagnostic service through participation in all

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