Postdoctoral Research Associate

4 weeks ago


University of York, United Kingdom University of York Full time

**Role**:
We are looking for a highly motivated Research Associate to work on a BBSRC-funded project aimed at characterising collisions of the bacterial replication machinery with protein obstacles. This project will exploit the biochemical tractability of Escherichia coli to investigate fundamental aspects of DNA replication at the DNA, protein and complex/super-complex level. The project will focus on studying the mechanistic consequences of replication obstacles for replisomes, resolution of replisome collisions by helicases, and understanding the impact of replication-transcription conflicts on genome duplication. Developing a full molecular understanding of replisome-obstacle collisions is currently a major challenge in the field because they can impede replication fork progression and cause genome instability.

**Department**:
**Key responsibilities**:
The main responsibilities are:

- To conduct research under the supervision of senior colleagues and to contribute to the production of research
- To assist in the identification and development of potential areas of research and the development of proposals for independent or collaborative research projects

**Skills, Experience & Qualifications needed**:

- Knowledge of a range of research techniques and methodologies.
- Research expertise in an area that will complement and enhance the department’s research strategy and goals.
- The ability to work as part of a team and independently using their initiative.
- Experience of writing up research work for publication.
- Willingness to engage in public dissemination of research.
- Highly developed communication skills (oral and written).
- The ability to plan and prioritise their own work to meet deadlines.
- Commitment to personal development and updating of knowledge and skills.

Interview date: TBC

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