Research Assistant
3 weeks ago
**Salary**:
**Research Assistant**: £30,619 to £32,411 per annum
**Research Associate**: £33,348 to £37,386 per annum
Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
**Closing Date**: 07 May 2023
The Role
Following recent success in securing a LifeArc project grant, we are seeking an experienced researcher to join our internationally renowned multi-disciplinary team in Newcastle, to take a lead role in the project “Use of antisense oligonucleotides as personalised therapies for kidney disease”.
The Project
**Renal ciliopathies**: disease mechanisms and therapeutics.
Nephronophthisis (NPHP), an autosomal recessive primary ciliopathy, is the most common cause of end-stage renal disease in children and young adults. Our research has revealed a critical role for hedgehog signalling in NPHP such that chemical agonists of smoothened can ameliorate disease phenotypes [Hynes et al. 2014. PNAS 111:9893-8; Srivastava et al. 2017. Hum Mol Genet 26:4657-67]. Subsequently, we have demonstrated the therapeutic potential of exon-skipping antisense oligonucleotides (ASO) in patient cells and mouse models in vivo [Ramsbottom et al. 2018. PNAS 115: 12489-94; Molinari et al. 2019. Sci Rep 9:10828]. We now wish to exploit a novel murine model of NPHP and use ASOs to determine the exact therapeutic benefit and tissue delivery and assess off target effects as a prelude to first in man studies.
This post is full time and fixed term for a period of 12 months
Find out more about the Faculty of Medical Sciences here.
Find out more about our Research Institutes here.
Key Accountabilities
Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
Determine appropriate methodologies for research, with advice and support where required
Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
Assess research findings for the need/scope for further investigations
Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
May contribute to events celebrating the public engagement of science/social sciences/humanities
Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
The Person (Essential)
Knowledge, Skills and Experience
Ability to work well as part of a team and rapidly acquire new skills
Likelihood of advanced skills directly related to the research projects
High level of analytical and problem-solving capability
Ability to communicate complex information with clarity and to encourage the commitment of others
Experience of research with clear transferable skills and some experience or awareness of the research environment
Presentations at conferences and/or high-quality publications
Extensive analytical experience, specifically fluorescent immunohistochemistry and quantitative RNA methods
Proficiency with utilising genomic tools and databases, with an understanding of bioinformatic tools and languages
Experience of supervising and guiding undergraduate and postgraduate research students
Experience of mouse genetics (Desirable)
UK Home Office Personal Licence (PIL A/B) (Desirable)
Attributes and Behaviour
High level laboratory skills, with attention to detail and the ability to critically analyse and interpret data
Outstanding organisational and record keeping skills, with the ability to plan and prioritise tasks to meet deadlines
Ability to contribute ideas and enhancements to develop the project and further research objectives
Contribution to dissemination of research via seminar, conference presentations or publications
Ability to work collaboratively in a multidisciplinary team, but also show strong independent working
Demonstrate enthusiasm towards scientific engagement (Desirable)
Confidence and willingness to support and guide research
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