Pbpk Modeller

**Company Overview**

Quotient Sciences is a drug development and manufacturing accelerator providing integrated programs and tailored services across the entire development pathway. Cutting through silos across a range of drug development capabilities, we save precious time and money in getting drugs to patients.

As a growing and successful business, we employ more than 1,100 talented individuals globally, located at state-of-the-art development, manufacturing and clinical facilities in the UK and USA.

Science, Agility and Culture are the core components that define Quotient Sciences, enabling us to do what we do in the way that we do it. People join Quotient Sciences because we are a respected member of the drug development community, driven by an unswerving belief that ideas need to become solutions, and molecules need to become cures, fast. Because humanity needs solutions, fast.

**The Role**

Due to growth and expansion, we are hiring a PBPK Modelling Research Fellow to join our Scientific consulting group. The role will provide hands-on modelling and simulation (M&S) scientific support to Quotients clients including first-in-human predictions, biopharmaceutic and formulation evaluations and drug drug interaction modelling.

**Key Tasks**
- Build and rigorously test PBPK models including performing parameter sensitivity analysis where appropriateusing GastroPlus and other relevant modelling data analysis packages.
- Assess IVIVC/IVIVR’s between in vitro dissolution data and plasma concentration time data using traditional numerical deconvolution methods and mechanistic absorption models.
- Interpret and present expert conclusions from modelling work to Quotient and client project teams throughout the project life-cycle.
- Critically review client data packages and prepare proposals for potential new modelling projects.
- Provide scientific support to Business Development (BD), Client Services and Scientific Consulting Group to effectively communicate Quotient’s modelling capabilities and offerings, to identify opportunities and develop these opportunities.
- Identification, preparation and presentation of peer reviewed publications, posters and presentations, including attendance at conferences and scientific meetings.
- Minimum degree level
- Significant experience in biopharm, PK data analysis, PK modelling, metabolism and/or clinical pharmacology
- Practical experience predicting human PK from preclinical data using e.g. physiologically based pharmacokinetic (PBPK) modelling or traditional “scaling” approaches
- Experience in the design and data interpretation of scientific studies to address key objectives

**Company Benefits**

In return, you will receive a competitive salary, a generous benefits package, excellent training and development, as well as an exciting career within a fast paced and dynamic business.

**Our commitment to Diversity & Inclusion**

Quotient Sciences business are advocates for positive change and conscious inclusion. We strive to create a diverse Quotient family by remaining committed to the development of our culture, equality, mindset, diversity & inclusions in the workplace.

As a global employer, we recognise the value in having an organisation that is a true reflection and representation of our society today. All applicants welcome.