Associate Principal Scientist Early Respiratory and

5 months ago

Cambridge, United Kingdom AstraZeneca Full time

**Associate Principal Scientist Early Respiratory and Immunology**

**Cambridge**

**Salary & Benefits competitive**

**Introduction to role**:
Join AstraZeneca, a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions. As part of the growing Immunology Bioscience team within the Early Respiratory & Immunology (Early R&I) department, we are seeking a highly motivated senior researcher with a strong understanding of adaptive and/or innate immunity. This role is based in Cambridge (UK) within AstraZeneca’s state-of-the-art laboratories in the Discovery Center (DISC).

**Accountabilities**:
In this role, you will focus your research on characterizing novel immunological pathways in health and disease to aid target validation and drug development. You will drive new target identification strategies and oversee the design and execution of bioscience in vitro and in vivo experiments. You will also develop and lead collaborations with disease experts, work closely with key leaders in partner functions to ensure project goals are met, and take an active role in growing and developing team members.

**Essential Skills/Experience**:

- Ph.D. in immunology or relevant research area, with multiple years of industry experience
- Expertise in drug discovery projects in immunology or a closely related field of biology
- Experience with multiple drug modalities, including large molecule, small molecule, or cell therapies
- Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team
- Strong understanding and technical skills in multiple biochemical and molecular techniques including primary cell culture, quantification of mRNA (qPCR), multi-panel flow cytometry/ CyTOF (including both intracellular and extracellular markers), protein expression, ELISA, Western blot, MSD, Luminex, etc.
- Ex vivo culture experience, working with primary human tissue samples, and knowledge of in vivo models of autoimmunity and inflammation.
- Experience in complex co-culture systems, cell imaging or precision immunology technologies
- Experience with mentoring students and post-doctoral scientists
- Possess an understanding of key biological pathways in immune-mediated diseases such as rheumatological and/or gastrointestinal diseases

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office/ lab. But that doesn't mean we're not flexible. We balance the expectation of being in the office/ lab while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Join us if you want to continuously learn and try new things. This is the place to build a meaningful career as we push the boundaries of science to deliver life-changing medicines. We are always listening and learning from people who live with the diseases our medicines treat. It enables us to better understand their needs and, ultimately, diagnose and design the right treatments to impact patients' lives.

Applications must include your current CV, and a cover letter which presents your motivation and suitability for the role.

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