Structural Biologist

**As a Structural Biologist (cryo-EM) you will have the opportunity to**:

- Solve structures of ligand-protein, protein-protein, and antibody-antigen complexes in a cryo-EM pipeline that will be integrated within Exscientia’s AI-driven design and automation platform for Biologics & Drug Discovery
- Enable high-throughput single particle cryo-EM analysis, focusing on grid preparation, data collection, image processing, & structural classification of multiple samples
- Perform epitope mapping studies at various atomic resolutions to validate computational design and docking protocols
- Support the implementation of automated cryo-EM data storage and processing on cloud infrastructure
- Liaise with internal and external partners, vendors, or consortia

**Requirements**:

- Ph.D. degree in Structural Biology, Biophysics, Biochemistry, or related disciplines, with graduate or postdoctoral experience focusing on the structural determination of biomolecules with cryo-EM
- Expert in single particle cryo-EM workflows: Specifically, protein purification, grid preparation, data collection, image processing, and 2D to 3D classification
- Proven background with relevant data processing software: For example, Phenix, Coot, Relion, CryoSPARC, Scipion, Topaz, RosettaEM
- Experience with model generation into cryo-EM densities using structure-prediction algorithms: For example, AlphaFold2, RosettaFold2, ModelAngelo, DeepTracer
- Experience with Biophysical methods for sample preparation & characterization, focusing on protein analytics, binding kinetics, and folding stability
- Preferred experience with high-throughput cryo-EM technology, such as EPU Multigrid
- Peer-reviewed publications focused on cryo-EM and related structural & biophysical characterization methods

**Benefits