Lyase/hydrogen Sulfide Pathway in Cardiomyopathy

2 months ago

Birmingham, United Kingdom Aston University Full time

Applications are invited for a three-year Postgraduate studentship, the College of Health and Life Sciences, to be undertaken at Aston University.

**The position is available to start in January 2024.**

**Financial Support**

**Background to the Project**

Cardiovascular diseases have been the leading cause of mortalities worldwide. There are approximately 4 million deaths per year due to heart diseases in Europe, accounting for nearly 50% of all deaths in Europe. Despite the advancements in medical technology, the morbidity and mortality rate of heart failure remains high. Compared to the 1990s, death due to heart failure increased by 54% in 2016, posing a significant global health problem.

There are several types of cardiomyopathies, including dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM) and arrhythmogenic right ventricle cardiomyopathy (ARVC), peripartum cardiomyopathy (PPCM) and Takotsubo (stress) cardiomyopathy, with DCM and HCM being the more general forms of the disease. Compare to DCM, a subset HCM patients who progress into dilated phase of HCM (D-HCM), have higher mortality risk than those with DCM. However, the underlying pathogenic mechanisms are not fully understood.

We have discovered that the hydrogen sulfide producing enzyme, cystathionine -lyase (CSE), plays an important role in cardiac function. Loss of this enzyme leads to a deteriorating left ventricle (LV) systolic function. This is associated with hypertrophic phenotypes and dilated LV suggesting that loss CSE may be involved in D-HCM.

The proposed study will test the central hypothesis that CSE/H2S pathway play a key role in normal cardiac function. Dysregulation of this pathway promotes and leads to the pathogenesis of cardiomyopathy.

This studentship will provide appropriate training for a graduate in compliance with the principles of good clinical practice, animal research, cellular and molecular biochemistry. The successful outcome of this work may lead to development of new diagnostic, prognostic and intervention tools for patients with cardiomyopathy.

**Person Specification**

**Contact information**
- A copy of your current CV
- Copies of your academic qualifications for your Bachelor degree, and Masters degree (if studied); this should include both certificates and transcripts, and must be translated in to English
- A research proposal statement*
- A personal statement
- Two academic references
- Proof of your English Language proficiency

**Please include the supervisor’s name, project title and project reference in your Personal Statement.

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