Postdoctoral Research Fellow

1 week ago

Stirling, United Kingdom University of Stirling Full time

**Post Details**
Full time
Fixed term for up to 32 months

Interviews are expected to take place on Monday 08 July 2024.

There is an expectation that work will be undertaken in the UK.

**The Post**
The researcher position being advertised is for a **32 months Full time Grade 7 Research Fellow post** to join an exciting collaborative project between University of Stirling’s Institute of Aquaculture, Moredun Research Institute, Bimeda Animal Health and Vertebrate Antibodies Ltd. to develop a mucosal vaccine for Atlantic salmon to protect against the skin parasite, salmon louse, _Lepeophtheirus salmonis_.

The successful applicant will work with Dr. Sean Monaghan (PI) and Prof. James Bron (Co-I) on the Biotechnology and Biological Science Research Council (BBSRC) funded project, “**Development of a mucosally-delivered and active salmon louse vaccine for Atlantic salmon aquaculture**” to produce an efficacious prototype salmon louse vaccine through reverse vaccinology. A novel aspect of the project is the incorporation of recently developed AI technology for novel antigen discovery. This will allow development of an oral vaccine to be delivered via mucosal antigen-presenting scaffolds.

The Research Fellow will organise and perform sea lice infection and vaccination fish challenge trials at the University of Stirling’s marine environmental research laboratory facility and use qPCR, RNA-sequencing and proteomics approaches to explore parasite life-stage relevant antigens of _Lepeophtheirus salmonis_.

**Description of Duties**
- Design and organise fish trials and sea lice experimental challenges
- Organise and assist with the collection of samples from fish at the Marine Environmental Research Laboratory (MERL), Argyll
- Travel to and work in remote areas of Scotland
- Design and organise vaccination-challenge trials at the Marine Environmental Research Laboratory (MERL), Argyll
- Develop and perform qPCR assays to determine immune gene expression from vaccinated fish
- Use proteomic approaches to assess key sea louse molecules involved in host-parasite interactions including work on secretory/excretory products (SEPs)
- Perform and support RNA-seq experiments on _Lepeophtheirus salmonis_ throughout different developmental stages of its life cycle
- Prepare protocols and risk assessments as required
- Contribute to the development of research objectives and proposals for own or joint research and play a lead role in relation to a specific project/s or part of a broader project with guidance from senior colleagues, if required and as appropriate for the duration of the appointment
- As part of the wider research team, develop new research methodologies and approaches. Write and contribute to peer-reviewed publications and disseminate research findings using appropriate media
- Contribute to new proposals, including drafting grant proposals and planning for future research, if required and as appropriate for the duration of the appointment
- Support supervision of undergraduate (BSc.) and postgraduate research students (PhD and MSc.) and contribute to teaching if required and as appropriate or the duration of the appointment by, for example, supervising practical work
- Build internal contacts and participate in internal networks for the exchange of information and to form relationships for future collaboration

**Essential Criteria** Qualifications**
- PhD (or equivalent) in a relevant discipline: _e.g_. molecular biology, immunology, parasitology, proteomics

**Knowledge, Skills & Experience**
- Possession of fundamental molecular biology lab skills (e.g. PCR, gel electrophoresis, RNA extraction etc.)
- Evidence of experience with RNA sequencing and/or allied transcriptomic techniques
- Evidence of working with experimental animals
- Evidence of ability to conduct high quality research work, and to disseminate results from such work
- Evidence for IT and data analysis / interpretation skills as appropriate e.g. experience with ‘R’ or other statistical software
- Evidence of a developing publication record

**Desirable Criteria** Qualifications**
- Membership of relevant Chartered/professional bodies (including Higher Education Academy)

**Knowledge, Skills & Experience**
- Experience with handling fish and taking tissue samples.
- Experience with fish vaccine trials
- Experience of undergraduate or postgraduate teaching and/or supervision of dissertations and research projects
- Evidence of experience with LC MS/MS and proteomic analysis.
- Evidence of ability to prepare written reports and deliver oral presentations
- Knowledge of parasitology
- Knowledge of immunology
- Knowledge of vaccinology
- Experience working under regulations controlling the use of animals in science
- Experience working in remote locations
- Driving licence

**Behaviours and Competencies**
The role holder will be required to evidence that they can meet the qualities associated with the following behavioural competencies,

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