Postdoctoral Research Associate

3 weeks ago

Edinburgh, United Kingdom University of Edinburgh Full time

**Grade UE07: £37,099 - £44,263 per annum **( A revised salary range for this grade of £39,347 to £46,974 is planned to take effect from Spring 2024)

**College of Science and Engineering / School of Biological Sciences / Institute of Quantitative Biology, Biochemistry and Biotechnology**

**Full time: 35 hours per week**

**Fixed Term: from 1 **st **April 2024 - 31 **st **March 2026 (24 months)**

We are looking for a driven and enthusiastic post-doctoral researcher interested in working on the post-transcriptional roles of Helix-Turn-Helix transcription factors in an important bacterial pathogen (MRSA).

**The Opportunity**:
We recently found that many Helix-Turn-Helix domain transcription factors (HTH-TFs) from methicillin-resistant _Staphylococcus aureus _also globally bind RNA _in vivo _. Some HTH-TFs have well-established transcriptional roles in regulating MRSA infectivity and antibiotic resistance. Moreover, the transcription activity of numerous HTH-TFs can be controlled by small molecules, making them promising targets for developing novel antimicrobials.

Our data indicate that the regulatory impact of HTH-TFs is much more profound than anticipated, underscoring the need for a thorough characterisation of these proteins. We hypothesise that HTH-TFs post-transcriptionally control a substantial fraction of antibiotic resistance and virulence factors by altering the stability/translation of RNA substrates. RNA may also compete with HTH-TF transcriptional activities.

By integrating state-of-the-art biochemical, structural, and phenotypic approaches, you will obtain detailed mechanistic insights into (i) how key HTH-TFs bind both DNA and RNA molecules, (ii) how small molecule effectors control this activity, and (iii) how these RNA-binding activities impact gene expression during host infection. A detailed understanding of MRSA HTH-TF function and how its nucleic acid binding is regulated may underpin future therapeutic approaches.

**Your skills and attributes for success**:

- Experience in structural and biophysical characterisation of protein-nucleic acid interactions
- Experience with analysis of large datasets using Python and/or R
- Demonstrated background in RNA Biology research.
- Experience in biochemical approaches for studying protein-nucleic acid interactions.
- Understanding of co
- and post-transcriptional regulation of gene expression.

**Click to view a copy of the full **job description **(opens new browser tab)

**As a valued member of our team you can expect**:

- A competitive salary.
- An exciting, positive, creative, challenging and rewarding place to work.
- To be part of a diverse and vibrant international community.
- Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our **staff benefits page **(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits.

**Championing equality, diversity and inclusion**

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our **right to work webpages **(opens new browser tab ).

**Key dates to note

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