Research Assistant/associate

3 days ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**:
**Research Assistant**: £31,396 to £32,982 per annum
**Research Associate**: £33,966 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 06 May 2024

The role

We seek an enthusiastic and experienced Cancer Researcher to join our team in the Newcastle Centre for Cancer.

Prostate cancer is the most common male malignancy, with approximately 1 in 8 men being diagnosed with prostate cancer in their lifetime. For men with advanced treatment resistant prostate cancer there are currently no curative therapies available and there is an urgent need to develop new treatment strategies. Immunotherapy has shown exciting promise for some solid tumours but has to date been ineffective for prostate cancer. Currently, it is unclear why prostate tumours are resistant to immunotherapy.

This project aims to investigate the role of androgen receptor (AR) regulation of O-glycosylation as a mechanism controlling CD8+ T cell activity. The proposed project will use a range of techniques, including western blotting, flow cytometry, glycan profiling and primary cell isolations to investigate the role of AR-controlled glycans in CD8+ T cell homeostasis and in anti-cancer activity.

This is an opportunity to address a key problem facing patients with prostate cancer and work towards an improved understanding of the mechanisms of resistance to immunotherapy. You will work as a part of a large group of prostate cancer researchers within the Newcastle Centre for Cancer.

This post is fixed term until 30/11/2024.

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities

Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
Determine appropriate methodologies for research, with advice and support where required
Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
Assess research findings for the need/scope for further investigations
Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
May contribute to events celebrating the public engagement of science/social sciences/humanities
Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment

The Person

Knowledge, Skills and Experience
Ability to work well as part of a team and rapidly acquire new skills
Specific experience of glycobiology techniques
Specific experience in primary cell isolation and culture
Likelihood of advanced skills directly related to the research projects
High level of analytical and problem-solving capability
Ability to communicate complex information with clarity and to encourage the commitment of others
Experience of research with clear transferable skills and some experience or awareness of the research environment
Presentations at conferences and/or high-quality publications
Desirable
Experience in molecular biology techniques (western blotting, qPCR, flow cytometry)
Demonstratable knowledge of prostate cancer research

Attributes and Behaviour
Excellent record keeping
Excellent teamwork skills

**Qualifications**:
A PhD in Cancer Research (Research Associate)
A Masters degree in or close to submission of a PhD in Cancer Research (for appointment at Assistant level)

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