Senior Bioinformatician

Salary within the range of £34,00 - £38,000 per annum (depending upon experience)
- Job Ref: MI/24/19
- Duration of post: Fixed term until 31 March 2027

**About the role**:
The CRUK National Biomarker Centre (NBC) has an international reputation for liquid biomarkers, with the aim to develop, validate and implement biomarkers that facilitate cancer precision medicine through improved cancer detection, prognosis prediction, and prediction and monitoring of patient response to therapy. Our research integrates clinical, molecular and computational science into a highly convergent programme, with advanced computational biology playing a critical role in our biomarker agenda.

**About you**:
You will have a Degree in computational biology/bioinformatics, or related discipline (or equivalent relevant experience) plus significant data analysis and/or bioinformatics pipeline experience. Alternatively, you will have a postgraduate degree related to cancer biology with demonstrable data analysis and/or bioinformatics pipeline experience.

You will have relevant experience in data analysis (preferably with R/Bioconductor or Python) and/or have experience working with bioinformatics pipelines (e.g. Nextflow), be able to work comfortably on the Linux command line. Having a grasp of the statistical approaches used to analyse genome-wide datasets would be an advantage. An understanding of liquid biopsies, cancer genomics, and/or cancer biology are also desirable. You will have strong communication skills and a desire to work collaboratively with scientists from other disciplines along with the ability to work well within a multidisciplinary team.

This role would be suitable for a specialist in data analysis and/or bioinformatics pipelines wishing to expand upon their cancer related knowledge, or a cancer bench scientist transitioning into a career in computational analysis.

**Why choose Cancer Research UK National Biomarker Centre?**

Our Centre discovers, develops, validates and qualifies biomarkers in clinical studies and trials that detect cancer earlier and predict and monitor therapy responses to support optimised treatment of patients with cancer. Our advanced research programmes, agnostic to cancer type, develop biomarkers in tissue and less invasive clinical samples such as blood (liquid biopsy) with sophisticated bioinformatic and artificial intelligence solutions for multi-modal laboratory and clinical biomarker data analysis and interpretation. Our preclinical programmes focus on development of pharmacodynamic biomarker and evaluation the efficacy of novel therapeutics in patient derived models. As a bridge between discovery science and clinical research, we are highly collaborative across Manchester, nationally and internationally.

The Cancer Biomarker Centre is located in the New Paterson Building, a £150 million flagship purpose-built biomedical research facility directly attached to The Christie NHS Foundation Trust in South Manchester. Situated on the third floor, the Cancer Biomarker Centre offers world-class research facilities with bespoke, purpose-built suite of laboratories in close proximity to discovery science collaborators and the Christie Hospitals clinical trialists.

Our Centres aim is to discover, develop, validate and qualify biomarkers that support optimised treatment of patients with cancer. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to translational research and biomarker driven clinical trials.

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
- Our University is positive about flexible working you can find out more_ _here_

**How to Apply**:
**Enquiries about the vacancy, shortlisting and interviews**:
Name: Dr Dominic Rothwell

**General enquiries**:
**Technical support**:
**Please see the link below for the Further Particulars document which contains the person specification criteria.