Research Fellow

1 month ago


Aberdeen, United Kingdom University of Aberdeen Full time

Research Fellow

**School/Section**
- Medicine, Medical Sciences & Nutrition

**Division**
- Institute of Medical Sciences

**Staff Category**
- Research

**Position Type**
- Full Time

**Duration of Post**
- Funding/Activity Limited

**Grade**
- Grade 6

**Salary From**
- £37,099

**Salary to**
- £40,521

**Location**
- Aberdeen

**Closing Date**
- 27/11/2023

**Ref No**
- IMS276R

**Documents**
- Further Particulars.pdf
(PDF, 1278.39kb)

We are recruiting for an exceptional individual as a Postdoctoral Research Fellow to work on the ‘How transcriptional regulation governs fungal drug resistance’ project funded by BBSRC.

Antifungal drug resistance is a serious clinical and societal problem when using drugs to treat infections in humans and other animals. A common cause of drug resistance is overexpression of 'efflux pump' genes, which greatly reduce the effectiveness of drugs by pumping them out of cells.

In this project, we will elucidate how expression of drug efflux pump genes is controlled in the pathogenic fungus Candida glabrata. C. glabrata infection is associated with high mortality in individuals with compromised immunity. C. glabrata is particularly deadly as a fungal pathogen because it has low susceptibility to azole antifungal agents, and easily develops drug resistance due to overproduction of efflux pumps. Preventing overexpression of these efflux pump genes is one good approach to ensure C. glabrata can be killed by existing antifungal drugs. However, overproduction mechanism of the pumps is not understood sufficiently well for us to prevent it.

Salary will be at the appropriate point on the Grade 6, £37,099 - £40,521 per annum and negotiable with placement according to qualifications and experience.

Job Reference Number**:IMS276R**
- The School of Medicine, Medical Sciences and Nutrition embraces a diverse working environment and recognises the many benefits this can bring. Applications from individuals from across all of the equality protected characteristics are encouraged._


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